Anti-Talin antibody [8D4]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Talin 2 and Talin 1 are closely related proteins that play important roles in cellular mechanics. Talin 1 sometimes referred to as TLN1 has a molecular mass of around 270 kDa. Talin 2 often called TLN2 shares structural and functional similarities with Talin 1. Both proteins serve as essential components of the focal adhesion complexes that connect integrins to the actin cytoskeleton. These proteins are widely expressed across various tissues with Talin 1 being more abundant in most cell types while Talin 2 shows more specific expression in muscle tissues.

Biological function summary

Talin proteins support cellular adhesion and migration by mediating integrin activation. Talin 1 and Talin 2 bind to integrins and recruit other proteins to form a multi-molecular complex. This interaction facilitates the connection between the extracellular matrix and the intracellular actin cytoskeleton allowing cells to respond to mechanical cues and move towards the desired direction. These functions are especially important in muscle contraction and cell motility processes.

Pathways

Talin proteins actively participate in the integrin signaling pathways. Within this pathway Talin interacts with key proteins such as vinculin and kindlin to modulate cellular adhesion. The integrin signaling pathway is important for various cellular processes including survival differentiation and migration. Through the actin cytoskeleton Talin-associated pathways also connect to the Rho GTPase signaling which regulates cytoskeletal dynamics.

Associated diseases and disorders

Altered expression or function of Talin proteins associates with various pathological conditions including cancer and muscular dystrophy. Talin 1 has implications in tumor progression through its role in enhancing cell migration and invasion essential processes in metastasis. In muscular dystrophy mutations or dysregulation of Talin 2 can affect muscle integrity and function contributing to disease pathogenesis. Both proteins interact with integrin and kindlin forming part of the complex network implicated in these disorders.