AB211870

Anti-TALLA-1 antibody [CL0262]

Name: Anti-TALLA-1 antibody [CL0262] (ab211870) | Abcam
Brand: Abcam Limited
SKU: AB211870

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(4 Publications)

Mouse Monoclonal TALLA-1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TSPAN7 aa 100 to C-terminus.

View Alternative Names

CD231, A15, DXS1692E, MXS1, TM4SF2, TSPAN7, Tetraspanin-7, Tspan-7, Cell surface glycoprotein A15, Membrane component chromosome X surface marker 1, T-cell acute lymphoblastic leukemia-associated antigen 1, Transmembrane 4 superfamily member 2, TALLA-1

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TALLA-1 antibody [CL0262] (AB211870)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TALLA-1 antibody [CL0262] (AB211870)

Immunohistochemical analysis of paraffin-embedded Human cerebral cortex tissue labeling TALLA-1 with ab211870 at 1/500 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TALLA-1 antibody [CL0262] (AB211870)

Immunohistochemical analysis of paraffin-embedded Human pancreas tissue labeling TALLA-1 with ab211870 at 1/500 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TALLA-1 antibody [CL0262] (AB211870)

Immunohistochemical analysis of paraffin-embedded Human cerebellum tissue labeling TALLA-1 with ab211870 at 1/500 dilution.

Supplier Data

Western blot - Anti-TALLA-1 antibody [CL0262] (AB211870)

All lanes:

Western blot - Anti-TALLA-1 antibody [CL0262] (ab211870) at 1/500 dilution

Lane 1:

Negative control (vector only transfected HEK293T lysate)

Lane 2:

TALLA-1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells)

Predicted band size: 28 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

CL0262

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TSPAN7 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P41732

Epitope

Binds to an epitope located within the peptide sequence NDERSRAVDHVQRSL as determined by overlapping synthetic peptides.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TALLA-1 also known as human T-cell acute lymphoblastic leukemia antigen 1 is a cell surface glycoprotein with a molecular weight of around 43 kDa. This protein is mainly expressed in T-cell acute lymphoblastic leukemia cells but not in normal mature T-cells making it a significant marker in specific pathological contexts. TALLA-1 has been studied for its role in cell adhesion and signal transduction indicating its function in cell communication and interaction.

Biological function summary

This protein plays an important role in malignant T-cell development and proliferation. Its activity influences T-cell receptor pathways which are critical in the immune response. TALLA-1 is not typically part of a larger protein complex but it interacts with other surface molecules to execute its functions particularly in aberrant T-cells.

Pathways

Studies have shown that TALLA-1 is integrated into the T-cell receptor signaling pathway and the leukemogenesis pathway. These pathways associate it with proteins such as CD3 and ZAP-70 which are essential for T-cell activation and progression of leukemogenesis. The interactions within these pathways highlight the significant role TALLA-1 plays in T-cell transformation and immune signaling.

TALLA-1 is prominently linked to T-cell acute lymphoblastic leukemia (T-ALL) and has been identified in cases of severe combined immunodeficiency (SCID). The protein's aberrant expression correlates with the aggressive nature of T-ALL where it serves as a biomarker for diagnosis and potential therapeutic target. Its interaction with pathways and other proteins like NOTCH1 further emphasizes its involvement in aberrant T-cell proliferative disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May be involved in cell proliferation and cell motility.

See full target information TSPAN7

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Canadian journal of gastroenterology & hepatology 2025:5209381 PubMed41031049

2025

TSPAN7 Functions as an Antitumor Agent Through the STK11/AMPK/mTOR Axis in Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Weng,Fenfen Hong

Frontiers in neurology 14:1255097 PubMed38020594

2023

Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.

Applications

Unspecified application

Species

Unspecified reactive species

Li Zhang,Jun Huang,Lu Dai,Gang Zhu,Xiao-Lin Yang,Zeng He,Yu-Hong Li,Hui Yang,Chun-Qing Zhang,Kai-Feng Shen,Ping Liang

Frontiers in immunology 14:1105489 PubMed36845098

2023

Functional characterization of TSPAN7 as a novel indicator for immunotherapy in glioma.

Applications

Unspecified application

Species

Unspecified reactive species

Long Chen,Hongwei Liu,Yanwen Li,Xuelei Lin,Shunjin Xia,Siyi Wanggou,Xuejun Li

American journal of cancer research 11:495-512 PubMed33575083

2021

A new 7-gene survival score assay for pancreatic cancer patient prognosis prediction.

Applications

Unspecified application

Species

Unspecified reactive species

Lisi Luo,Yufang Li,Chumei Huang,Yujing Lin,Yonghui Su,Hong Cen,Yutong Chen,Siqi Peng,Tianyi Ren,Rongzhi Xie,Linjuan Zeng

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TALLA-1 antibody [CL0262]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TALLA-1 antibody [CL0262] (AB211870)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TALLA-1 antibody [CL0262] (AB211870)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TALLA-1 antibody [CL0262] (AB211870)

Western blot - Anti-TALLA-1 antibody [CL0262] (AB211870)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Epitope

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise