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AB230359

Anti-TAM41 antibody

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(2 Publications)

Rabbit Polyclonal TAM41 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TAMM41 aa 150 to C-terminus.

View Alternative Names

C3orf31, TAMM41, CDP-diacylglycerol synthase, Mitochondrial translocator assembly and maintenance protein 41 homolog, CDP-DAG synthase, TAM41

4 Images
Immunocytochemistry/ Immunofluorescence - Anti-TAM41 antibody (AB230359)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TAM41 antibody (AB230359)

PC-3 (human prostate adenocarcinoma cell line) cells stained for TAM41 (green) using ab230359 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® congugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAM41 antibody (AB230359)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAM41 antibody (AB230359)

Paraffin-embedded human glioma cancer tissue stained for TAM41 using ab230359 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAM41 antibody (AB230359)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAM41 antibody (AB230359)

Paraffin-embedded human kidney tissue stained for TAM41 using ab230359 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-TAM41 antibody (AB230359)
  • WB

Supplier Data

Western blot - Anti-TAM41 antibody (AB230359)

All lanes:

Western blot - Anti-TAM41 antibody (ab230359) at 1/1000 dilution

All lanes:

Mouse brain lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 51 kDa

Observed band size: 51 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TAMM41 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96BW9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TAM41 also known as TPRKB is a mitochondrial matrix protein with a molecular mass of approximately 41 kDa. It plays an important role in the biosynthesis of cardiolipin an important phospholipid for mitochondrial function. TAM41 is found mostly in the inner mitochondrial membrane where it actively participates in remodeling processes. Expression of TAM41 occurs in various tissues with the highest abundance in organs with high-energy demands like the heart and skeletal muscle.
Biological function summary

TAM41 is essential for proper mitochondrial maintenance by contributing to the cardiolipin biosynthesis pathway. This protein functions within a larger complex involved in lipid metabolism interacting with other proteins to facilitate the synthesis and integration of cardiolipin into the mitochondrial membrane. Through these actions TAM41 supports mitochondrial architecture and energy metabolism processes impacting cellular energy homeostasis.

Pathways

TAM41 operates within the cardiolipin biosynthesis and remodeling pathways. These pathways are integral to maintaining mitochondrial membrane stability and function. Interaction with proteins such as CRD1 and PGPS connects TAM41 to the essential mechanisms of lipid transport and assembly ensuring proper cellular energetics and mitochondrial dynamics.

Research links TAM41 to mitochondrial-related conditions particularly Barth syndrome. Mutations or dysregulation in TAM41 can compromise cardiolipin synthesis leading to cardiomyopathy and muscle weakness seen in these patients. Additionally interactions with CLD1 influence TAM41's involvement in conditions related to mitochondrial dysfunction highlighting its importance in maintaining mitochondrial integrity and health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
See full target information TAMM41
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell reports. Medicine 5:101653 PubMed39019009

2024

Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Clàudia Gil-Pitarch,Marina Serrano-Maciá,Jorge Simon,Laura Mosca,Carolina Conter,Claudia M Rejano-Gordillo,L Estefanía Zapata-Pavas,Patricia Peña-Sanfélix,Mikel Azkargorta,Rubén Rodríguez-Agudo,Sofía Lachiondo-Ortega,Maria Mercado-Gómez,Teresa C Delgado,Marina Porcelli,Igor Aurrekoetxea,James D Sutherland,Rosa Barrio,Dimitris Xirodimas,Patricia Aspichueta,Felix Elortza,Luis Alfonso Martínez-Cruz,Rubén Nogueiras,Paula Iruzubieta,Javier Crespo,Steven Masson,Misti Vanette McCain,Helen L Reeves,Raul J Andrade,M Isabel Lucena,Ugo Mayor,Naroa Goikoetxea-Usandizaga,Irene González-Recio,María L Martínez-Chantar

Redox biology 69:103013 PubMed38168657

2024

Endothelial TET2 regulates the white adipose browning and metabolism via fatty acid oxidation in obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Yefei Shi,Xinru Huang,Yanxi Zeng,Ming Zhai,Hongyun Yao,Chang Liu,Bo Li,Shiyu Gong,Qing Yu,Jianhui Zhuang,Yifan Zhao,Liesheng Lu,Bo Zhou,Weixia Jian,Wenhui Peng
View all publications
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