Rabbit Polyclonal TAOK2 phospho S181 antibody. Suitable for WB and reacts with Rat samples. Immunogen corresponding to Synthetic Peptide within Human TAOK2 phospho S181.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.5
Constituents: HEPES, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.01% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TAOK2 phospho S181. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UL54
Reactivity data
Select an application| WB | |
|---|---|
| Human | Predicted |
| Mouse | Predicted |
| Rat | Tested |
| Dog | Predicted |
| Zebrafish | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1/1000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Dog, Human, Zebrafish, Mouse | Dilution info - | Notes - |
Target data
Function
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.
Alternative names
KIAA0881, MAP3K17, PSK, PSK1, UNQ2971/PRO7431, TAOK2, Serine/threonine-protein kinase TAO2, Kinase from chicken homolog C, Prostate-derived sterile 20-like kinase 1, Thousand and one amino acid protein kinase 2, hKFC-C, PSK-1, Prostate-derived STE20-like kinase 1
Recommended products
Rabbit Polyclonal TAOK2 phospho S181 antibody. Suitable for WB and reacts with Rat samples. Immunogen corresponding to Synthetic Peptide within Human TAOK2 phospho S181.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.5
Constituents: HEPES, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.01% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TAOK2 phospho S181. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UL54
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
The antibody is prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TAOK2 a serine/threonine-protein kinase also known as TAO2 is a member of the thousand and one amino acid kinases family. It is a 130 kDa protein that participates in various cellular processes by transferring phosphate groups to serine and threonine residues on substrate proteins. TAOK2 is part of the cytoplasmic signaling pathway and shows expression in different tissues especially in the brain. It plays important roles by interacting with cellular machinery to perform its functions effectively within the cell.
- Biological function summary
TAOK2 is instrumental in modulating cytoskeletal dynamics impacting processes such as neuron morphology and dendritic branching. TAOK2 associates with complexes involved in microtubule assembly influencing cell division and intracellular transport. Its activity affects neuronal connectivity impacting neural development and synaptic function which are critical in the nervous system. This makes its regulation necessary for normal brain function and development.
- Pathways
TAOK2 integrates into the MAPK signaling pathway affecting cell responses to stress and cytokines. This pathway is important for initiating cellular responses to external stimuli such as changes in the environment or cellular damage. TAOK2 phosphorylates other proteins such as MEK3 MEK6 and p38 MAP kinases influencing downstream signaling cascades. It also interacts with proteins involved in the Wnt signaling pathway contributing to cell differentiation proliferation and the maintenance of stem cells.
- Associated diseases and disorders
TAOK2 has links to neurodevelopmental disorders and schizophrenia. Mutations and dysregulations in TAOK2 expression correlate with developmental abnormalities in the brain potentially leading to conditions like autism spectrum disorder. Furthermore its interaction with proteins such as DISC1 a schizophrenia-associated protein suggests a role in psychiatric disorders. TAOK2's involvement in altering neural architecture highlights its importance in maintaining neuropsychiatric health.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-TAOK2 (phospho S181) antibody (ab254136)
All lanes: Western blot - Anti-TAOK2 (phospho S181) antibody (ab254136) at 1/1000 dilution
Lane 1: Rat cortical lysate
Lane 2: Rat cortical lysate treated with lambda phosphatase (1200 units for 30 mins)
Predicted band size: 138 kDa
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