Anti-TAOK2 + TAOK1 + TAOK3 (phospho S177 + S181 + S181) antibody [EPR4883]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TAOK2 TAOK1 and TAOK3 are members of the TAO (thousand and one amino acid) kinase family which are serine/threonine protein kinases. These kinases are known alternative names such as KINASE ORCCAN and MAP3K16. They operate through the phosphorylation of substrates to relay signals within cells a vital function in maintaining cellular processes. TAOK family proteins have varying molecular masses with TAOK2 weighing around 130 kDa. These kinases exhibit broad expression in the human body but are notably present in the brain suggesting a significant role in neurological functions.

Biological function summary

TAOK family kinases participate in the regulation of cell cycle apoptosis and stress response. They interact with various signaling complexes serving important roles in maintaining cellular homeostasis. Their ability to influence cytoskeletal dynamics further highlights their involvement in controlling cell morphology and mobility. Their activity is therefore important in ensuring that cells respond appropriately to internal and external stimuli promoting overall cellular health and function.

Pathways

The TAOK family kinases engage actively in the MAPK signaling cascade and JNK signaling pathway. Their engagement in these pathways links them to other proteins such as MAPK14 and JNK3 which play pivotal roles in transmitting stress signals thereby enabling adaptation and survival mechanisms within cells. These signaling routes allow cells to adjust to changes in the environment by regulating gene expression and cellular responses.

Associated diseases and disorders

Altered TAOK kinase activity connects to neurodevelopmental disorders such as autism spectrum disorder and neurodegenerative conditions like Alzheimer's disease. Disruptions in TAOK signaling may affect proteins such as NRXN1 and APP known for their roles in synaptic function and neuronal integrity respectively. These connections emphasize the importance of TAOK kinases in neural tissue and highlight potential avenues for therapeutic interventions targeting these kinases in relevant neurological diseases.