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AB127190

Anti-TAPBP-R antibody

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(1 Publication)

Rabbit Polyclonal TAPBP-R antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TAPBPL aa 100 to C-terminus.

View Alternative Names

Tapasin-related protein, TAPASIN-R, TAP-binding protein-like, TAP-binding protein-related protein, Tapasin-like, TAPBP-R, TAPBPL

1 Images
Western blot - Anti-TAPBP-R antibody (AB127190)
  • WB

Unknown

Western blot - Anti-TAPBP-R antibody (AB127190)

10% SDS Page

All lanes:

Western blot - Anti-TAPBP-R antibody (ab127190) at 1/1000 dilution

Lane 1:

293T whole cell lysate at 30 µg

Lane 2:

A431 whole cell lysate at 30 µg

Predicted band size: 50 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human TAPBPL aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BX59

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TAPBP-R also known as Tapasin-related protein is a protein that mechanically facilitates immune function by assisting in the assembly and stabilization of the major histocompatibility complex (MHC) Class I molecules. It weighs approximately 46 kDa. TAPBP-R is expressed widely across various tissues with notable presence in the thymus and lymph nodes. It plays a significant role in immune surveillance and the presentation of antigenic peptides.
Biological function summary

TAPBP-R interacts in the peptide loading complex which supports the proper folding and peptide binding to MHC Class I molecules. This interaction allows effective antigen presentation necessary for the immune response. TAPBP-R works alongside other components of the peptide loading complex including TAP1 and TAP2 transporters calnexin and ERp57 contributing significantly to immune function.

Pathways

TAPBP-R operates within the antigen processing and presentation pathway. This protein aligns closely with the MHC Class I antigen presentation pathway where TAP1 and TAP2 are essential partners. Within this system TAPBP-R optimizes MHC Class I assembly coordinating with key pathway proteins to maintain efficient immune surveillance and responses against pathogens.

TAPBP-R links with conditions such as autoimmune diseases and cancer. Abnormalities in TAPBP-R expression or function can disrupt antigen presentation influencing the progression of autoimmune disorders. Additionally TAPBP-R connects with proteins like MHC Class I in cancer where its modified expression might facilitate immune evasion by tumor cells. Understanding these interactions provides insights into therapeutic targets and immune modulation in such diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).
See full target information TAPBPL
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 32: PubMed40709397

2025

Pan‑cancer analysis of the carcinogenic role of WSB2 in human tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Yingzi Deng,Yifei Li,Ruobing Li,Xiaohui Guo,Yan Liu,Shuqing Wang,Juan Zhang,Mi Li,Lina Zhao,Haifeng Cai,Yunfeng Zhang,Fen Hu
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Product promise

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