Anti-TAPBP-R antibody [OTI1C9]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TAPBP-R also known as Tapasin-related protein is a protein that mechanically facilitates immune function by assisting in the assembly and stabilization of the major histocompatibility complex (MHC) Class I molecules. It weighs approximately 46 kDa. TAPBP-R is expressed widely across various tissues with notable presence in the thymus and lymph nodes. It plays a significant role in immune surveillance and the presentation of antigenic peptides.

Biological function summary

TAPBP-R interacts in the peptide loading complex which supports the proper folding and peptide binding to MHC Class I molecules. This interaction allows effective antigen presentation necessary for the immune response. TAPBP-R works alongside other components of the peptide loading complex including TAP1 and TAP2 transporters calnexin and ERp57 contributing significantly to immune function.

Pathways

TAPBP-R operates within the antigen processing and presentation pathway. This protein aligns closely with the MHC Class I antigen presentation pathway where TAP1 and TAP2 are essential partners. Within this system TAPBP-R optimizes MHC Class I assembly coordinating with key pathway proteins to maintain efficient immune surveillance and responses against pathogens.

Associated diseases and disorders

TAPBP-R links with conditions such as autoimmune diseases and cancer. Abnormalities in TAPBP-R expression or function can disrupt antigen presentation influencing the progression of autoimmune disorders. Additionally TAPBP-R connects with proteins like MHC Class I in cancer where its modified expression might facilitate immune evasion by tumor cells. Understanding these interactions provides insights into therapeutic targets and immune modulation in such diseases.