Anti-TAS2R14 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

TAS2R14 functions as a part of the taste signaling mechanism. It does not operate within a complex system but plays a direct role in detecting structurally diverse bitter molecules. Activation of TAS2R14 leads to a biochemical cascade that involves the release of internal calcium stores causing depolarization of the gustatory cells. This process generates neural signals that the brain interprets as the perception of bitterness. TAS2R14's role extends beyond taste influencing metabolic processes and protective reflexive actions.

Pathways

TAS2R14 participates in the taste transduction pathway where it activates intracellular signaling through the gustducin protein alpha subunit. This pathway is essential for converting chemical signals from the binding of bitter substances into electrical impulses that the brain can comprehend. TAS2R14 is also connected to the phospholipase C beta 2 (PLCβ2) pathway which plays an important role in signal amplification. Through these pathways TAS2R14 interacts with related proteins like GNAT3 which further transmits the bitter taste signals.