Anti-TAS2R14 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TAS2R14 also known as T2R14 is a bitter taste receptor with a molecular weight of approximately 37 kDa. It is a G protein-coupled receptor (GPCR) categorized under the taste 2 receptor family. TAS2R14 is expressed in various tissues notably in the taste buds of the tongue and the gastrointestinal tract. It detects bitter compounds and triggers signaling pathways that lead to taste perception. The receptor belongs to a larger family involved in taste transduction allowing for the discrimination of different bitter substances.

Biological function summary

TAS2R14 functions as a part of the taste signaling mechanism. It does not operate within a complex system but plays a direct role in detecting structurally diverse bitter molecules. Activation of TAS2R14 leads to a biochemical cascade that involves the release of internal calcium stores causing depolarization of the gustatory cells. This process generates neural signals that the brain interprets as the perception of bitterness. TAS2R14's role extends beyond taste influencing metabolic processes and protective reflexive actions.

Pathways

TAS2R14 participates in the taste transduction pathway where it activates intracellular signaling through the gustducin protein alpha subunit. This pathway is essential for converting chemical signals from the binding of bitter substances into electrical impulses that the brain can comprehend. TAS2R14 is also connected to the phospholipase C beta 2 (PLCβ2) pathway which plays an important role in signal amplification. Through these pathways TAS2R14 interacts with related proteins like GNAT3 which further transmits the bitter taste signals.

Associated diseases and disorders

TAS2R14 is linked to conditions such as chronic rhinosinusitis and asthma. The receptor's expression in extra-oral tissues suggests a role in modulating inflammatory responses possibly through interactions with cytokine-producing pathways. TAS2R14 may connect to proteins involved in these conditions such as certain inflammatory markers influencing susceptibility or severity. The receptor's activity highlights an intersection between taste perception and immune responses offering potential therapeutic targets for related disorders.