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AB138199

Anti-TAS2R39 antibody

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Rabbit Polyclonal TAS2R39 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Taste receptor type 2 member 39.

View Alternative Names

Taste receptor type 2 member 39, T2R39, Taste receptor type 2 member 57, T2R57, TAS2R39

1 Images
Western blot - Anti-TAS2R39 antibody (AB138199)
  • WB

Unknown

Western blot - Anti-TAS2R39 antibody (AB138199)

All lanes:

Western blot - Anti-TAS2R39 antibody (ab138199) at 1/500 dilution

All lanes:

HepG2 cell lysate at 30 µg

Predicted band size: 35 kDa,39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Taste receptor type 2 member 39. The exact immunogen used to generate this antibody is proprietary information.

P59534

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab138199 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TAS2R39 also known as taste receptor type 2 member 39 is a protein responsible for the detection of bitter compounds. It belongs to the G-protein-coupled receptor (GPCR) family and has a role in taste perception. The molecular mass of TAS2R39 is approximately 27 kDa. Expression of TAS2R39 occurs in the taste receptor cells of the tongue specifically in the taste buds. The protein is pivotal in recognizing and transducing signals associated with various bitter substances.
Biological function summary

TAS2R39 functions as a critical receptor for bitter taste recognition contributing to the sense of taste in organisms. The receptor is part of a complex signaling network that involves the binding of bitter compounds triggering intracellular signaling cascades. Activation of TAS2R39 induces conformational changes in the receptor leading to the activation of associated G proteins that convey the signal within taste cells ultimately resulting in a bitter taste sensation.

Pathways

TAS2R39 operates within the bitter taste transduction pathway and plays a major role in the gustatory signaling system. This receptor interacts closely with the gustducin protein a G protein involved in taste signaling pathways. The functional cascade prompted by TAS2R39 activation illustrates how taste perception integrates into the larger network of sensory transduction pathways essential for interpreting gustatory stimuli.

TAS2R39 has associations with variations in taste perception contributing potentially to dietary choices that affect overall health. Alterations in TAS2R39 function or expression could influence the risk of nutritional imbalances that stem from aversions to certain bitter-tasting nutrients. Additionally TAS2R39 is linked to the regulation of innate immune response by modulating bacterial infection in the upper airway with involvement of proteins such as TLRs (toll-like receptors) that play roles in pathogen detection and immune system activation.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
See full target information Taste receptor type 2 member 39

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