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Sheep Polyclonal TAU antibody. Suitable for IHC-P, ICC/IF, IHC-Fr and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TAU_HUMAN aa 1-50.


Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau antibody (AB62639), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-Tau antibody (AB62639), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-Tau antibody (AB62639), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau antibody (AB62639), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau antibody (AB62639), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Sheep

Storage buffer

Preservative: 0.02% Thimerosal (merthiolate)
Constituents: Whole serum

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human TAU_HUMAN aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link P10636

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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PICC/IFIHC-Fr
Human
Tested
Tested
Expected
Chimpanzee
Predicted
Predicted
Predicted
Gorilla
Predicted
Predicted
Predicted
Orangutan
Predicted
Predicted
Predicted
Rhesus monkey
Predicted
Predicted
Predicted

Tested
Tested

Species

Human

Dilution info

1/4000 - 1/8000

Notes

-

Predicted
Predicted

Species

Chimpanzee, Rhesus monkey, Gorilla, Orangutan

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

1/400 - 1/800

Notes

-

Predicted
Predicted

Species

Chimpanzee, Rhesus monkey, Gorilla, Orangutan

Dilution info

-

Notes

-

Expected
Expected

Species

Human

Dilution info

Use at an assay dependent concentration.

Notes

-

Predicted
Predicted

Species

Chimpanzee, Rhesus monkey, Gorilla, Orangutan

Dilution info

-

Notes

-

Associated Products

Select an associated product type

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Target data

Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Targets

Microtubule-associated protein tau

Alternative names

Recommended products

Sheep Polyclonal TAU antibody. Suitable for IHC-P, ICC/IF, IHC-Fr and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TAU_HUMAN aa 1-50.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human TAU_HUMAN aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link P10636
Purity

Whole antiserum

Specificity

The specificity of this antibody refers to P10636-8.

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Tau also known as microtubule-associated protein Tau (MAPT) plays an important role in stabilizing microtubules in neuronal cells. Tau is primarily found in the central nervous system but also exists in peripheral neurons. Human Tau protein comes in six isoforms due to alternative splicing with molecular weights ranging from 48 kDa to 67 kDa. This protein predominantly locates in the axons of neurons where it maintains the stability of microtubule tracks necessary for axonal transport.

Biological function summary

Tau is involved in the assembly and stabilization of microtubules essential for maintaining neuronal structure. It interacts with microtubule-binding domains (MBD) to bind and bundle microtubules facilitating intracellular transport. Tau forms a part of the neuronal cytoskeleton complex working closely with other cytoskeletal proteins to preserve the proper axonal transport and function. Abnormally phosphorylated Tau often termed phospho-Tau disrupts this complex affecting microtubule stability.

Pathways

Tau has critical involvement in several signaling cascades such as the microtubule-binding and transport pathways. Glycogen synthase kinase 3 beta (GSK3β) and cyclin-dependent kinase 5 (CDK5) frequently phosphorylate Tau controlling its interaction with microtubules. Phosphorylated Tau accumulates leading to the formation of neurofibrillary tangles often observed in neurodegenerative conditions. Additionally Tau interacts with GAPDH impacting cellular energy regulation through potential pathway cross-talk involving oxidative stress responses.

Associated diseases and disorders

Tau is closely associated with Alzheimer's disease and frontotemporal dementia. In Alzheimer's disease hyperphosphorylated Tau aggregates into paired helical filaments forming neurofibrillary tangles while similar aggregates are observed in frontotemporal dementia. In these conditions Tau links to amyloid precursor protein (APP) where misregulated phosphorylation-driven interactions contribute to neurodegeneration. Identifying phospho-Tau and its altered interactions with related proteins aids in understanding and potentially treating these disorders.

Product promise

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5 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau antibody (ab62639), expandable thumbnail
    This image is courtesy of a customer review submitted by Carl Hobbs, King's College London, United Kingdom

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau antibody (ab62639)

    IHC-P image of Tau staining on Human colon tissue section using ab62639 (1/4000). The section were subjected to heat mediated antigen retrieval using citric acid (pH 6). The sections were then blocked using 1% BSA for 10 min at 21°C. The primary antibody was incubated for 2 hours at 21°C.

  • Immunocytochemistry/ Immunofluorescence - Anti-Tau antibody (ab62639), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-Tau antibody (ab62639)

    ab62639 at 1/400 dilution staining Tau in neurons by confocal Immunohistochemistry. Jackson Cy2 secondary
    antibody (1/100).

  • Immunocytochemistry/ Immunofluorescence - Anti-Tau antibody (ab62639), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-Tau antibody (ab62639)

    ab62639 at 1/400 dilution staining Tau in dystrophic neurites within plaques by confocal Immunohistochemistry. Jackson Cy2 secondary antibody (1/100).

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau antibody (ab62639), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau antibody (ab62639)

    ab62639 at 1/8000 staining Tau in neurons within neuronal axons Tau threads (as indicated by arrows), by Light Immunohistochemsitry. Jackson biotinylated donkey anti rabbit secondary antibody (1/2000) followed by Sigma Extra avidin peroxidase (1/400) and DAB substrate.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau antibody (ab62639), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau antibody (ab62639)

    ab62639 at 1/8000 staining Tau in dystrophic neurites within plaques, within neuronal axons Tau threads (as indicated by arrows), by Light Immunohistochemsitry. Jackson biotinylated donkey anti rabbit secondary antibody (1/2000) followed by Sigma Extra avidin peroxidase (1/400) and DAB substrate.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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