AB254410

Anti-Tau (phospho T205) antibody [EPR23505-13]

BOND RX™ Validated
20ul selling size
RabMAb
Recombinant
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(9 Publications)

Rabbit Recombinant Monoclonal TAU phospho T205 antibody. Suitable for IHC-P, IP, Dot, WB, AP, IHC-Fr, I-ELISA and reacts with Rat, Human, Mouse, Synthetic peptide - Human samples. Cited in 9 publications.

View Alternative Names

MAPTL, MTBT1, TAU, MAPT, Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPTL, MTBT1, TAU, MAPT, Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau

13 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Immunohistochemical analysis of paraffin-embedded Human breast tissue labeling Tau (phospho T205) with ab254410 at 1/20000 dilution followed by a ready to use Rabbit specific IHC polymer detection kit HRP/DAB (ab209101). Positive staining on human breast without alkaline phosphatase treatment (image A, PMID : 15914550). No signal was detected when tissues were treated with alkaline phosphatase (image B). The section was incubated with ab254410 for 10 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND^® RX instrument. Counterstained with Hematoxylin.

Secondary antibody only control : Secondary antibody is a ready to use Rabbit specific IHC polymer detection kit HRP/DAB (ab209101).

Heat mediated antigen retrieval with Citrate buffer (pH 6.0, epitope retrieval solution 1) for 10 mins.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Immunohistochemical analysis of paraffin-embedded Human Alzheimer's disease cerebrum tissue labeling Tau (phospho T205) with ab254410 at 1/20000 dilution followed by a ready to use Rabbit specific IHC polymer detection kit HRP/DAB (ab209101). Positive staining on human Alzheimer's disease cerebrum without alkaline phosphatase treatment (image A, PMID : 20631843). No signal was detected when tissues were treated with alkaline phosphatase (image B). The section was incubated with ab254410 for 10 mins at room temperature.The immunostaining was performed on a Leica Biosystems BOND^® RX instrument. Counterstained with Hematoxylin.

Secondary antibody only control : Secondary antibody is a ready to use Rabbit specific IHC polymer detection kit HRP/DAB (ab209101).

Heat mediated antigen retrieval with Citrate buffer (pH 6.0, epitope retrieval solution 1) for 10 mins.

Indirect ELISA - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

I-ELISA

Lab

Indirect ELISA - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Indirect ELISA analysis of ab254410 at 1000-0 ng/ml. The Secondary antibody used was Alkaline Phosphatase-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) at 1 : 2500 dilution.

Antigen : Human MAPT(phospho T205) peptide, Human MAPT non-phospho peptide

Antigen concentration : 1000 ng/ml.

Immunohistochemistry (Frozen sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Immunohistochemical analysis of 4% PFA-fixed, 0.2% Triton X-100 permeabilized frozen Rat cerebrum tissue labeling Tau (phospho T205) with ab254410 at 1/500 (1.034 ug/ml) dilution followed by ab150077 Goat Anti-Rabbit IgG H&L (Alexa Fluor^® 488) at 1/1000 dilution (Green). Positive staining on rat cerebrum, while nearly no staining on rat cerebrum after alkaline phosphatase (AP) treatment. The nuclear counterstain was DAPI (Blue).

Secondary antibody control : Secondary antibody is ab150077 Goat Anti-Rabbit IgG H&L (Alexa Fluor^® 488)at 1/1000 dilution.

Heat mediated antigen retrieval using sodium citrate buffer (10mM citrate pH 6.0 + 0.05% Tween-20).

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Immunohistochemical analysis of paraffin-embedded Rat cerebrum tissue labeling Tau (phospho T205) with ab254410 at 1/20000 dilution followed by a ready to use Rabbit specific IHC polymer detection kit HRP/DAB (ab209101). Positive staining on rat cerebrum without alkaline phosphatase treatment (image A, PMID : 28035925). No signal was detected when tissues were treated with alkaline phosphatase (image B).The section was incubated with ab254410 for 10 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND^® RX instrument. Counterstained with Hematoxylin.

Secondary antibody only control : Secondary antibody is a ready to use Rabbit specific IHC polymer detection kit HRP/DAB (ab209101).

Heat mediated antigen retrieval with Citrate buffer (pH 6.0, epitope retrieval solution 1) for 10 mins.

IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Immunohistochemical analysis of 4% PFA-fixed, 0.2% Triton X-100 permeabilized frozen Mouse cerebrum tissue labeling Tau (phospho T205) with ab254410 at 1/500 (1.034 ug/ml) dilution followed by ab150077 Goat Anti-Rabbit IgG H&L (Alexa Fluor^® 488) at 1/1000 dilution (Green). Positive staining on mouse cerebrum, while nearly no staining on mouse cerebrum after alkaline phosphatase (AP) treatment. The nuclear counterstain was DAPI (Blue).

Secondary antibody control : Secondary antibody is ab150077 Goat Anti-Rabbit IgG H&L (Alexa Fluor^® 488) at 1/1000 dilution.

Heat mediated antigen retrieval using sodium citrate buffer (10mM citrate pH 6.0 + 0.05% Tween-20).

Unknown

Immunoprecipitation - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Tau (phospho T205) was immunoprecipitated from 0.35 mg Rat brain tissue lysate with ab254410 at 1/30 dilution (2ug in 0.35mg lysates). Western blot was performed on the immunoprecipitate using ab254410 at 1/1000 dilution. VeriBlot for IP Detection Reagent (HRP)(ab131366) was used at 1/5000 dilution.

Lane 1 : Rat brain tissue lysate 10 ug

Lane 2 : ab254410 IP in Rat brain tissue lysate

Lane 3 : Rabbit monoclonal IgG (ab172730) instead of ab254410 in Rat brain tissue lysate

Blocking and dilution buffer and concentration : 5% NFDM/TBST.

Exposure time : 3 minutes.

All lanes:

Immunoprecipitation - Anti-Tau (phospho T205) antibody [EPR23505-13] (ab254410)

Predicted band size: 78 kDa

Observed band size: 50-70 kDa

false

Unknown

Immunoprecipitation - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Tau (phospho T205) was immunoprecipitated from 0.35 mg Mouse brain tissue lysate with ab254410 at 1/30 dilution (2ug in 0.35mg lysates). Western blot was performed on the immunoprecipitate using ab254410 at 1/1000 dilution. VeriBlot for IP Detection Reagent (HRP)(ab131366) was used at 1/5000 dilution.

Lane 1 : Mouse brain tissue lysate 10 ug

Lane 2 : ab254410 IP in Mouse brain tissue lysate

Lane 3 : Rabbit monoclonal IgG (ab172730) instead of ab254410 in Mouse brain tissue lysate

Blocking and dilution buffer and concentration : 5% NFDM/TBST.

Exposure time : 10 seconds.

All lanes:

Immunoprecipitation - Anti-Tau (phospho T205) antibody [EPR23505-13] (ab254410)

Predicted band size: 78 kDa

Observed band size: 50-70 kDa

false

Unknown

Western blot - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Blocking and dilution buffer : 5% NFDM/TBST.

Exposure time : 3 minutes.

The molecular weight observed is consistent with what has been described in the literature (PMID : 21722209).

All lanes:

Western blot - Anti-Tau (phospho T205) antibody [EPR23505-13] (ab254410) at 1/1000 dilution

Lane 1:

Human brain tissue lysate at 10 µg

Lane 2:

Human brain tissue lysate (phosphatase treated membrane) at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Predicted band size: 78 kDa

Observed band size: 50-70 kDa

false

Lab

Affinity Purification - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Biotinylated Tau (phospho T205) peptide [0.1 μg/ml] was loaded to SA biosensor on Fortebio RED96e Machine, then associate with recombinant Anti-Tau (phospho T205) antibody [EPR23505-13] in serial concentration points [6.67, 3.33, 1.67, 0.83, 0.42 nM/mL] by 2-fold dilution, next to dissociate in blank testing buffer [0.1% BSA in PBST (0.05%Tween-20)]. Calculated signals had already subtracted blank control, curve fitting using 1 : 1 binding model. Non-phospho Tau peptide' association and dissociation were also showed in graph. KD(M) value of Anti-Tau (phospho T205) antibody [EPR23505-13] is <1.0E-12

Unknown

Western blot - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Blocking and dilution buffer : 5% NFDM/TBST.

Exposure time : 48 seconds.

The molecular weight observed is consistent with what has been described in the literature (PMID : 21722209).

All lanes:

Western blot - Anti-Tau (phospho T205) antibody [EPR23505-13] (ab254410) at 1/1000 dilution

Lane 1:

Rat hippocampus tissue lysate at 10 µg

Lane 2:

Rat hippocampus tissue lysate (phosphatase treated membrane) at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Predicted band size: 78 kDa

Observed band size: 50-70 kDa

false

Unknown

Western blot - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Blocking and dilution buffer : 5% NFDM/TBST.

Exposure time : 70 seconds.

The molecular weight observed is consistent with what has been described in the literature (PMID : 21722209).

All lanes:

Western blot - Anti-Tau (phospho T205) antibody [EPR23505-13] (ab254410) at 1/1000 dilution

Lane 1:

Mouse brain tissue lysate at 10 µg

Lane 2:

Mouse brain tissue lysate (phosphatase treated membrane) at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Predicted band size: 78 kDa

Observed band size: 50-70 kDa

false

Supplier Data

Dot Blot - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Dot blot analysis of Tau (phospho T205) labeled with ab254410 at 1/1000 dilution.

Lane 1 : Tau (phospho S202+T205) peptide (aa 199-211).

Lane 2 : Tau (phospho S202+T205) peptide (aa 197-209).

Lane 3 : Tau peptide (aa 197-211).

Lane 4 : Tau (phospho S202) peptide (aa 197-211).

Lane 5 : Tau (phospho T205) peptide (aa 197-211).

Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/100000 dilution was used as secondary antibody.

Blocking and dilution buffer : 5% NFDM/TBST.

Exposure time : 3 minutes.

Carrier free

Anti-Tau (phospho T205) antibody [EPR23505-13] - BSA and Azide free
660 APC

APC Anti-Tau (phospho T205) antibody [EPR23505-13]
519 Alexa Fluor® 488

Alexa Fluor® 488 Anti-Tau (phospho T205) antibody [EPR23505-13]
565 Alexa Fluor® 555

Alexa Fluor® 555 Anti-Tau (phospho T205) antibody [EPR23505-13]
617 Alexa Fluor® 594

Alexa Fluor® 594 Anti-Tau (phospho T205) antibody [EPR23505-13]
665 Alexa Fluor® 647

Alexa Fluor® 647 Anti-Tau (phospho T205) antibody [EPR23505-13]
775 Alexa Fluor® 750

Alexa Fluor® 750 Anti-Tau (phospho T205) antibody [EPR23505-13]
Biotin

Biotin Anti-Tau (phospho T205) antibody [EPR23505-13]
578 PE

PE Anti-Tau (phospho T205) antibody [EPR23505-13]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR23505-13

Isotype

IgG

Carrier free

Reacts with

Rat, Human, Mouse

Applications

I-ELISA, Dot, IHC-P, AP, IHC-Fr, WB, IP

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

The specificity of this antibody refers to P10636-8.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "Dot" : {"fullname" : "Dot Blot", "shortname":"Dot"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "AP" : {"fullname" : "Affinity Purification", "shortname":"AP"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "IELISA" : {"fullname" : "Indirect ELISA", "shortname":"I-ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20000", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "1/30", "IP-species-notes": "", "Dot-species-checked": "guaranteed", "Dot-species-dilution-info": "", "Dot-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "AP-species-checked": "testedAndGuaranteed", "AP-species-dilution-info": "", "AP-species-notes": "Antibody concentration range - 6.67, 3.33, 1.67, 0.83, 0.42, 0 nM/mL", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "IELISA-species-checked": "guaranteed", "IELISA-species-dilution-info": "", "IELISA-species-notes": "" }, "Mouse": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "1/20000", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/30", "IP-species-notes": "", "Dot-species-checked": "guaranteed", "Dot-species-dilution-info": "", "Dot-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "AP-species-checked": "guaranteed", "AP-species-dilution-info": "", "AP-species-notes": "", "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/500", "IHCFr-species-notes": "Heat mediated antigen retrieval using sodium citrate buffer (10mM citrate pH 6.0 + 0.05% Tween-20).", "IELISA-species-checked": "guaranteed", "IELISA-species-dilution-info": "", "IELISA-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20000", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/30", "IP-species-notes": "", "Dot-species-checked": "guaranteed", "Dot-species-dilution-info": "", "Dot-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "AP-species-checked": "guaranteed", "AP-species-dilution-info": "", "AP-species-notes": "", "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/500", "IHCFr-species-notes": "Heat mediated antigen retrieval using sodium citrate buffer (10mM citrate pH 6.0 + 0.05% Tween-20).", "IELISA-species-checked": "guaranteed", "IELISA-species-dilution-info": "", "IELISA-species-notes": "" }, "Synthetic peptide - Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "Dot-species-checked": "testedAndGuaranteed", "Dot-species-dilution-info": "1/1000", "Dot-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "AP-species-checked": "notRecommended", "AP-species-dilution-info": "", "AP-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "IELISA-species-checked": "testedAndGuaranteed", "IELISA-species-dilution-info": "31.25 ng/mL", "IELISA-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tau also known as microtubule-associated protein Tau (MAPT) plays an important role in stabilizing microtubules in neuronal cells. Tau is primarily found in the central nervous system but also exists in peripheral neurons. Human Tau protein comes in six isoforms due to alternative splicing with molecular weights ranging from 48 kDa to 67 kDa. This protein predominantly locates in the axons of neurons where it maintains the stability of microtubule tracks necessary for axonal transport.

Biological function summary

Tau is involved in the assembly and stabilization of microtubules essential for maintaining neuronal structure. It interacts with microtubule-binding domains (MBD) to bind and bundle microtubules facilitating intracellular transport. Tau forms a part of the neuronal cytoskeleton complex working closely with other cytoskeletal proteins to preserve the proper axonal transport and function. Abnormally phosphorylated Tau often termed phospho-Tau disrupts this complex affecting microtubule stability.

Pathways

Tau has critical involvement in several signaling cascades such as the microtubule-binding and transport pathways. Glycogen synthase kinase 3 beta (GSK3β) and cyclin-dependent kinase 5 (CDK5) frequently phosphorylate Tau controlling its interaction with microtubules. Phosphorylated Tau accumulates leading to the formation of neurofibrillary tangles often observed in neurodegenerative conditions. Additionally Tau interacts with GAPDH impacting cellular energy regulation through potential pathway cross-talk involving oxidative stress responses.

Tau is closely associated with Alzheimer's disease and frontotemporal dementia. In Alzheimer's disease hyperphosphorylated Tau aggregates into paired helical filaments forming neurofibrillary tangles while similar aggregates are observed in frontotemporal dementia. In these conditions Tau links to amyloid precursor protein (APP) where misregulated phosphorylation-driven interactions contribute to neurodegeneration. Identifying phospho-Tau and its altered interactions with related proteins aids in understanding and potentially treating these disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed : 21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed : 21985311, PubMed : 32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

See full target information MAPT phospho T205

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Neuropsychiatric disease and treatment 21:1911-1933 PubMed40926795

2025

Integrated Gut Microbiota, Metabolomics, and Network Pharmacology to Investigate the Anti-Alzheimer's Mechanism of Tripterygium Glycoside.

Applications

Unspecified application

Species

Unspecified reactive species

Yongcang Zhang,Quxi Silang,Yan Wang,Niannian Wang,Luobu Gesang,Liang Tang,Lan Liu

Exploration (Beijing, China) 5:e20230178 PubMed40873646

2025

Enhanced Blood-Brain Barrier Penetrability of BACE1 SiRNA-Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyuan Ding,Yanyu Hu,Xiaotong Feng,Zekun Wang,Qile Song,Chunxue Dai,Bangjia Yang,Xiaoyan Fu,Dongdong Sun,Cundong Fan

Neuromolecular medicine 27:34 PubMed40374872

2025

Far-Infrared Radiation Ameliorates the Cognitive Dysfunction in an Alzheimer's Disease Transgenic Mouse via Modulating Jak-2/Stat3 and Nrf-2/HO-1 Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Yang,Qiuxia Yu,Nick Wang,Koon Kit Lam,Zhi-Xiu Lin,Yan-Fang Xian

Scientific reports 13:20388 PubMed37989873

2023

Extracellular vesicles of human glial cells exert neuroprotective effects via brain miRNA modulation in a rat model of traumatic brain injury.

Applications

Unspecified application

Species

Unspecified reactive species

Diana I Salikhova,Angelika V Timofeeva,Victoria V Golovicheva,Timur Kh Fatkhudinov,Yulia A Shevtsova,Anna G Soboleva,Ivan S Fedorov,Kirill V Goryunov,Alexander S Dyakonov,Victoria O Mokrousova,Margarita O Shedenkova,Andrey V Elchaninov,Oleg V Makhnach,Sergey I Kutsev,Vladimir P Chekhonin,Denis N Silachev,Dmitry V Goldshtein

Journal of neuroinflammation 20:19 PubMed36717922

2023

Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer's disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qing-Qing Xu,Zi-Ren Su,Wen Yang,Mei Zhong,Yan-Fang Xian,Zhi-Xiu Lin

Cell reports 40:111433 PubMed36170830

2022

Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice.

Applications

Unspecified application

Species

Unspecified reactive species

Margarita Brilkova,Martina Nigri,Harshitha Santhosh Kumar,James Moore,Matilde Mantovani,Claudia Keller,Amandine Grimm,Anne Eckert,Dimitri Shcherbakov,Rashid Akbergenov,Petra Seebeck,Stefanie D Krämer,David P Wolfer,Thomas C Gent,Erik C Böttger

Neural regeneration research 18:189-193 PubMed35799541

2022

Lamotrigine protects against cognitive deficits, synapse and nerve cell damage, and hallmark neuropathologies in a mouse model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Xin-Xin Fu,Rui Duan,Si-Yu Wang,Qiao-Quan Zhang,Bin Wei,Ting Huang,Peng-Yu Gong, Yan E,Teng Jiang,Ying-Dong Zhang

Molecular neurodegeneration 16:78 PubMed34809709

2021

CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice.

Applications

Unspecified application

Species

Unspecified reactive species

Biju Bhargavan,Shawna M Woollard,Jo Ellyn McMillan,Georgette D Kanmogne

iScience 24:102993 PubMed34505007

2021

Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease.

Applications

Unspecified application

Species

Unspecified reactive species

Jorge A Aguilar-Pineda,Karin J Vera-Lopez,Pallavi Shrivastava,Miguel A Chávez-Fumagalli,Rita Nieto-Montesinos,Karla L Alvarez-Fernandez,Luis D Goyzueta Mamani,Gonzalo Davila Del-Carpio,Badhin Gomez-Valdez,Clint L Miller,Rajeev Malhotra,Mark E Lindsay,Christian L Lino Cardenas

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Tau (phospho T205) antibody [EPR23505-13]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Indirect ELISA - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Immunohistochemistry (Frozen sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Immunohistochemistry (Frozen sections) - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Immunoprecipitation - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Immunoprecipitation - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Western blot - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Affinity Purification - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Western blot - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Western blot - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Dot Blot - Anti-Tau (phospho T205) antibody [EPR23505-13] (AB254410)

Related conjugates and formulations (9)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

Product promise