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AB9448

Anti-Taurine antibody

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(2 Publications)

Rabbit Polyclonal Taurine antibody. Suitable for ICC, IHC-FoFr, IM, IHC-Fr and reacts with Chemical samples. Cited in 2 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to Taurine.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

IM, IHC-Fr, ICC, IHC-FoFr

applications

Specificity

The antibody is calibrated against a spectrum of antigens to assure hapten selectivity. Fixed tissue cross-reactivity was tested with known targets at the recommended dilution. No measurable glutaraldehyde-fixed tissue cross-reactivity (<1:1000) was detected against L-alanine, gamma-aminobutyrate, agmatine, guanidine, D/L-arginine, L-citrulline, L-cysteine, D/L-glutamate, D/L-glutamine, glutathione, glycine, L-lysine, L-ornithine, L-serine, L-threonine, L-tryptophan, L-tyrosine.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "IHCFoFr" : {"fullname" : "Immunohistochemistry (PFA perfusion fixed frozen sections)", "shortname":"IHC-FoFr"}, "IM" : {"fullname" : "Immunomicroscopy", "shortname":"IM"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "IHCFoFr-species-checked": "guaranteed", "IHCFoFr-species-dilution-info": "", "IHCFoFr-species-notes": "<p></p>", "IM-species-checked": "guaranteed", "IM-species-dilution-info": "", "IM-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
IgG fraction
Storage buffer
Preservative: 0.05% Thimerosal (merthiolate) Constituents: PBS, 1% Goat Serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Taurine often referred to as 2-aminoethanesulfonic acid is a small organic compound with a molecular mass of approximately 125 Da. It is not a classic amino acid used in protein synthesis but it plays many roles in various biological systems. Taurine is highly expressed in many tissues including the brain retina heart and skeletal muscle. It acts as an osmolyte helping to stabilize cell membranes and maintain the ionic balance inside cells. Additionally taurine contributes to bile salt formation in the liver.
Biological function summary

Taurine serves various functions that support survival and health. It acts as an antioxidant reducing oxidative stress by neutralizing reactive oxygen species. Taurine also participates in calcium signaling which is essential for muscle contraction and neurotransmitter release. While it is not part of a larger protein complex it interacts closely with membrane receptors and ion channels modulating their activity and contributing to cellular homeostasis.

Pathways

Taurine is integral to pathways such as bile acid biosynthesis and calcium signaling. In bile acid synthesis taurine conjugates with bile acids increasing their solubility and functionality in fat digestion and cholesterol metabolism. In the calcium signaling pathway taurine interacts with proteins like the ryanodine receptor and the sodium-calcium exchanger regulating calcium homeostasis in excitable tissues.

Taurine's deficiency or imbalance relates to conditions like retinitis pigmentosa and heart failure. In retinitis pigmentosa taurine contributes to the survival of photoreceptor cells alongside proteins like rhodopsin and a lack of taurine accelerates degeneration. In heart failure taurine impacts cardiac contractility and stress response interacting with proteins such as the sodium-calcium exchanger to maintain calcium equilibrium which is important for heart function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Taurine
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

eLife 12: PubMed38739438

2024

Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Yiyi Chen,Laimdota Zizmare,Victor Calbiague,Lan Wang,Shirley Yu,Fritz W Herberg,Oliver Schmachtenberg,Francois Paquet-Durand,Christoph Trautwein

The Journal of comparative neurology 505:92-113 PubMed17729258

2007

Metabolic and functional profiling of the normal rat retina.

Applications

IHC

Species

Rat

Daniel Sun,Algis J Vingrys,Michael Kalloniatis
View all publications
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Product promise

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