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AB56191

Anti-TBC1D1 antibody

4

(1 Review)

|

(3 Publications)

Rabbit Polyclonal TBC1D1 antibody. Suitable for ELISA, WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

KIAA1108, TBC1D1, TBC1 domain family member 1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ELISA, WB

applications

Immunogen

Synthetic Peptide within Human TBC1D1. The exact immunogen used to generate this antibody is proprietary information.

Q86TI0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purified by antigen specific affinity chromatography.
Storage buffer
pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TBC1D1 also known as TBC1 domain family member 1 is a protein involved in the regulation of glucose metabolism. It acts as a GTPase-activating protein (GAP) specifically for the Rab family of small GTPases. TBC1D1 plays a role in the activation and translocation of glucose transporter type 4 (GLUT4) to the plasma membrane. This protein has a molecular mass of approximately 130 kDa. It is highly expressed in skeletal muscle and brown adipose tissue indicating its role in energy homeostasis.
Biological function summary

TBC1D1 participates in the regulation of insulin-stimulated glucose uptake. It is not part of a multi-protein complex but it interacts with other proteins to execute its functions. TBC1D1 has a significant role in metabolic processes influencing how cells respond to insulin. By acting on GLUT4 TBC1D1 facilitates glucose entry into cells which is an important step in maintaining glucose levels in the blood.

Pathways

TBC1D1 is critical in the insulin signaling and AMP-activated protein kinase (AMPK) pathways. It interacts with proteins such as Akt and AS160 which are important in mediating the effects of insulin. In the insulin signaling pathway TBC1D1 regulates GLUT4 translocation while in the AMPK pathway it contributes to energy balance and metabolism. These pathways highlight the role of TBC1D1 in maintaining cellular energy efficiency and glucose homeostasis.

TBC1D1 has relevance to obesity and type 2 diabetes. Variants in the TBC1D1 gene have been associated with obesity suggesting the gene's role in body weight regulation. Additionally disruptions in TBC1D1 function might influence insulin resistance an important feature of type 2 diabetes. The protein plays a part in this by regulating GLUT4 translocation and glucose uptake associating it with metabolic syndrome components.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity).
See full target information TBC1D1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of applied physiology (Bethesda, Md. : 198 128:350-361 PubMed31895596

2020

Sex and fiber type independently influence AMPK, TBC1D1, and TBC1D4 at rest and during recovery from high-intensity exercise in humans.

Applications

Unspecified application

Species

Unspecified reactive species

Irene S Tobias,Kara K Lazauskas,Jeremy Siu,Pablo B Costa,Jared W Coburn,Andrew J Galpin

Diabetes 63:3748-58 PubMed24879834

2014

The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Kenneth K Y Cheng,Weidong Zhu,Bin Chen,Yu Wang,Donghai Wu,Gary Sweeney,Baile Wang,Karen S L Lam,Aimin Xu

PloS one 6:e27854 PubMed22114711

2011

GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance.

Applications

WB

Species

Human

Ulla Kampmann,Britt Christensen,Thomas Svava Nielsen,Steen Bønløkke Pedersen,Lotte Ørskov,Sten Lund,Niels Møller,Niels Jessen
View all publications
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