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AB235544

Anti-TBC1D14 antibody

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(2 Publications)

Rabbit Polyclonal TBC1D14 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TBC1D14 aa 100-450.

View Alternative Names

KIAA1322, TBC1D14, TBC1 domain family member 14

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBC1D14 antibody (AB235544)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBC1D14 antibody (AB235544)

Paraffin-embedded human brain tissue stained for TBC1D14 with ab235544 (1/100 dilution) in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBC1D14 antibody (AB235544)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBC1D14 antibody (AB235544)

Paraffin-embedded human adrenal gland tissue stained for TBC1D14 with ab235544 (1/100 dilution) in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TBC1D14 aa 100-450. The exact immunogen used to generate this antibody is proprietary information.

Q9P2M4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TBC1D14 also known as TBC1 domain family member 14 is a protein involved in regulating intracellular trafficking particularly in the context of autophagy and endosomal sorting. It has a mass of approximately 70 kDa and is widely expressed in human tissues including the brain liver and heart. The protein functions as a Rab GTPase-activating protein (GAP) and is responsible for modulating the activity of small GTPases which are essential for vesicle dynamics and trafficking processes.
Biological function summary

TBC1D14 plays an important role in coordinating membrane trafficking pathways by interacting with different proteins involved in autophagic processes. TBC1D14 associates with the ULK1 complex which is important for initiating autophagy. Through its interactions it regulates the formation and maturation of autophagosomes which are structures that sequester and degrade cellular components. TBC1D14's function is important for maintaining cellular homeostasis and responding to stress conditions that induce autophagy.

Pathways

TBC1D14 is involved in the regulation of the autophagy and endosomal sorting pathways. It connects to the key protein ULK1 and modulates autophagy. TBC1D14 also impacts the endosomal sorting complex required for transport (ESCRT) pathway which is necessary for endosomal trafficking. Through these pathways TBC1D14 facilitates the coordination and function of key cellular processes ensuring proper protein and organelle turnover.

TBC1D14 has connections to neurodegenerative diseases and cancer. Inefficient autophagy caused by TBC1D14 dysregulation can contribute to the accumulation of toxic protein aggregates seen in conditions like Alzheimer's disease. In cancer aberrant expression or activity of TBC1D14 can affect cell growth and survival. The protein's interactions with key regulators like ULK1 and components of the ESCRT machinery highlight its role in disease pathogenesis and potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the regulation of starvation-induced autophagosome formation (PubMed : 22613832). Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy.
See full target information TBC1D14
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:3 PubMed39762211

2025

Anti-PD-1 exacerbates bleomycin-induced lung injury in mice via Caspase-3/GSDME-mediated pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Wang,Haiyi Deng,Maolin Zhou,Yilin Yang,Jiankui Zhou,Yansheng Wang,Xiaohong Xie,Xinqing Lin,Ming Liu,Gengyun Sun,Chengzhi Zhou

PeerJ 12:e17362 PubMed38766486

2024

A comprehensive analysis of the oncogenic and prognostic role of TBC1Ds in human hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Pei Zhang,Lei Zhu,Xiaodong Pan
View all publications
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Product promise

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