Anti-TBC1D15 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TBC1D15 also known as TBC1 Domain Family Member 15 is a Rab GTPase-activating protein (Rab-GAP) with a molecular mass of approximately 72 kDa. This protein predominantly functions to regulate intracellular membrane trafficking by inactivating Rab GTPases such as Rab7 and Rab36. These Rab GTPases play essential roles in various cellular processes including endocytosis and vesicular trafficking. TBC1D15 is widely expressed in various tissues but demonstrated higher levels in the brain and skeletal muscle indicating tissue-specific roles or regulation.

Biological function summary

TBC1D15 contributes to mitochondrial dynamics and autophagy processes. It functions as part of a complex with the fission protein Fis1 on the mitochondrial outer membrane. By binding to Fis1 TBC1D15 plays an important role in mediating mitochondrial fission. This activity is interconnected with cellular energy homeostasis and quality control reflecting its influence on cellular health and survival. In the context of autophagy TBC1D15 regulation appears to ensure proper cargo selection and vesicle trafficking efficiency essential steps in cellular waste management.

Pathways

TBC1D15 participates in the mitophagy pathway and endocytic recycling pathway. The mitophagy pathway involves the removal of damaged mitochondrian important for cellular homeostasis and metabolism where TBC1D15 interacts with proteins such as Fis1 and Drp1 to facilitate mitochondrial division. In the endocytic recycling pathway TBC1D15 associates with Rab7 an important player in lysosome function and autophagy affecting cargo sorting and membrane turnover which are necessary for maintaining cellular balance and adapting to stress.

Associated diseases and disorders

Changes in TBC1D15 activity have been linked to neurodegenerative conditions including Parkinson's disease and Alzheimer's disease. These diseases often feature mitochondrial dysfunction and defective autophagy processes in which TBC1D15 plays a significant role. Aberrations in its interaction with proteins like Rab7 and Fis1 may contribute to the pathological environment seen in these diseases emphasizing its potential as a therapeutic target or biomarker for mitochondrial-related pathologies.