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AB234723

Anti-TBC1D24 antibody

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(3 Publications)

Rabbit Polyclonal TBC1D24 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TBC1D24 aa 1-200.

View Alternative Names

KIAA1171, TBC1D24, TBC1 domain family member 24

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-TBC1D24 antibody (AB234723)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TBC1D24 antibody (AB234723)

HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for TBC1D24 (Green) using ab234723 at 1/100 dilution in ICC/IF. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBC1D24 antibody (AB234723)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBC1D24 antibody (AB234723)

Paraffin-embedded human kidney tissue stained for TBC1D24 using ab234723 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBC1D24 antibody (AB234723)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBC1D24 antibody (AB234723)

Paraffin-embedded human pancreas tissue stained for TBC1D24 using ab234723 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TBC1D24 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q9ULP9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TBC1D24 also known by other names like TRE2-BUB2-CDC16 domain family member 24 functions as a GTPase-activating protein (GAP) for Rab GTPases. Its mass is approximately 66 kDa. This protein is expressed in various tissues including brain and inner ear. It plays a part in the regulation of vesicle trafficking and exocytosis by mediating the hydrolysis of GTP on Rab proteins which is essential for modulating their activity.
Biological function summary

TBC1D24 is involved in the control of neuronal signaling and synaptic function. The protein associates with the synaptic vesicle cycle influencing neurotransmitter release. It is not known to form part of larger protein complexes but it does work closely with other proteins to maintain synaptic efficiency and fidelity. This biological function makes it significant in neural tissue and brain function.

Pathways

TBC1D24 plays a role in processes related to synaptic vesicle trafficking and autophagy. It interacts with components of the Rab family serving as a regulatory factor within these pathways. The protein is linked to Rab35 and other related Rab proteins affecting how cellular materials are transported and recycled ensuring efficient cellular functions.

Mutations in TBC1D24 are connected to epilepsy and nonsyndromic hearing loss. The protein's relation to neural transmission links it to epilepsy where it influences excitatory and inhibitory balances in the brain. Additionally TBC1D24 interacts with several other proteins linked to synaptic function like synapsins indicating its importance in maintaining proper synaptic transmission and preventing neural disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May act as a GTPase-activating protein for Rab family protein(s) (PubMed : 20727515, PubMed : 20797691). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed : 20727515). Involved in the regulation of synaptic vesicle trafficking (PubMed : 31257402).
See full target information TBC1D24
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

BMC cancer 24:508 PubMed39103807

2024

Identification and validation of genes associated with prognosis of cisplatin-resistant ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Dajiang Liu,Ruiyun Li,Yidan Wang,Dan Li,Leilei Li

Cell stem cell 30:677-688.e5 PubMed37019105

2023

Generation of ventralized human thalamic organoids with thalamic reticular nucleus.

Applications

Unspecified application

Species

Unspecified reactive species

Ferdi Ridvan Kiral,Bilal Cakir,Yoshiaki Tanaka,Jonghun Kim,Woo Sub Yang,Fabien Wehbe,Young-Jin Kang,Mei Zhong,Gizem Sancer,Sang-Hun Lee,Yangfei Xiang,In-Hyun Park

Genes 11: PubMed32987832

2020

Mouse Models of Human Pathogenic Variants of Associated with Non-Syndromic Deafness DFNB86 and DFNA65 and Syndromes Involving Deafness.

Applications

Unspecified application

Species

Unspecified reactive species

Risa Tona,Ivan A Lopez,Cristina Fenollar-Ferrer,Rabia Faridi,Claudio Anselmi,Asma A Khan,Mohsin Shahzad,Robert J Morell,Shoujun Gu,Michael Hoa,Lijin Dong,Akira Ishiyama,Inna A Belyantseva,Sheikh Riazuddin,Thomas B Friedman
View all publications
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