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AB187168

Anti-TBC1D9B antibody [EPR12604(2)] - C-terminal

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(1 Publication)

Rabbit Recombinant Monoclonal TBC1D9B antibody. C-terminal. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

KIAA0676, TBC1D9B, TBC1 domain family member 9B

1 Images
Western blot - Anti-TBC1D9B antibody [EPR12604(2)] - C-terminal (AB187168)
  • WB

Supplier Data

Western blot - Anti-TBC1D9B antibody [EPR12604(2)] - C-terminal (AB187168)

Blocking buffer : 5% NFDM/TBST

All lanes:

Western blot - Anti-TBC1D9B antibody [EPR12604(2)] - C-terminal (ab187168) at 1/1000 dilution

Lane 1:

HeLa cell lysate at 20 µg

Lane 2:

Human fetal brain lysate at 20 µg

Lane 3:

PC-3 cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 141 kDa

Observed band size: 160 kDa

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  • Carrier free

    Anti-TBC1D9B antibody [EPR12604(2)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12604(2)

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TBC1D9B also known as TBC domain family member 9B is a protein characterized by its role as a GTPase-activating protein for Rab family proteins. It has a molecular mass of approximately 145 kDa. TBC1D9B is expressed widely in human tissues including but not limited to the heart brain and skeletal muscle. This protein interacts with small GTPases regulating their cycle of activation and inactivation which is important for intracellular trafficking processes.
Biological function summary

TBC1D9B participates in the regulation of endosomal dynamics and autophagy. This protein is part of the broader Rab GTPase network influencing vesicular transport and membrane fusion events within the cell. In various tissues TBC1D9B modulates cellular functions such as receptor recycling and protein degradation thereby maintaining cellular homeostasis. The protein's role in endosomal transport is particularly important in neurons where it impacts synaptic vesicle cycling.

Pathways

Several intracellular trafficking pathways engage TBC1D9B. It plays a significant role in the insulin signaling pathway and the endocytic pathway. By interacting with pathways such as these TBC1D9B influences the proper functioning of Rab GTPases notably Rab11. This association is vital for controlling endosomal sorting and recycling processes that are instrumental in various cellular activities like nutrient uptake and signaling cascades linked with cell growth and metabolism.

Certain pathologies demonstrate a connection with TBC1D9B. Alterations in its function have been implicated in diabetes due to the protein's influence on insulin action and glucose regulation. Additionally abnormal activity of TBC1D9B links to neurodegenerative conditions given its critical role in neural trafficking processes. The relationship between TBC1D9B and Rab GTPases like Rab11 underlines its importance in the pathophysiology of these disorders influencing disease progression through impaired vesicular transport.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May act as a GTPase-activating protein for Rab family protein(s).
See full target information TBC1D9B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of immunopathology and pharmacology 39:3946320251318147 PubMed39936565

2025

Melatonin alleviates oral epithelial cell inflammation via Keap1/Nrf2 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Zhang,Wenjing Wang,Rongxia Zhang,Yaxuan Liu,Yamei Wang,Yang Bai,Chencong Li
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com