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Rabbit Polyclonal TBR1 antibody. Suitable for WB and reacts with Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human TBR1 aa 100-400.

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Images

Western blot - Anti-TBR1 antibody (AB151587), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human TBR1 aa 100-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q16650

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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Predicted
Mouse
Tested
Rat
Predicted
Cow
Predicted
Xenopus tropicalis
Predicted

Tested
Tested

Species

Mouse

Dilution info

1/500 - 1/3000

Notes

-

Predicted
Predicted

Species

Rat, Cow, Human, Xenopus tropicalis

Dilution info

-

Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:25232744, PubMed:30250039). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity).

Alternative names

Recommended products

Rabbit Polyclonal TBR1 antibody. Suitable for WB and reacts with Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human TBR1 aa 100-400.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human TBR1 aa 100-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q16650
Purification technique

Affinity purification Immunogen

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TBR1 also known as T-Box Brain 1 is a transcription factor important for neuronal development. It weighs about 74 kDa. This protein is strongly expressed in the cerebral cortex during prenatal stages where it plays a role in regulating gene expression. TBR1 influences the differentiation and migration of cortical neurons which is critical for proper brain development.

Biological function summary

TBR1 influences neuronal differentiation through its function as a transcription factor. It binds to specific DNA sequences to regulate gene expression required for neuronal identity and function. TBR1 is part of a larger transcriptional complex that includes other proteins like CASK and TBR2 contributing to the maturation of cortical neurons. TBR1's role in these processes highlights its significance in neuronal circuit formation in the cerebral cortex.

Pathways

TBR1 is involved in the Wnt signaling and the reelin pathway which are both essential for normal brain development. In the Wnt signaling pathway TBR1 interacts with proteins such as LEF1 to influence cell fate decision and pattern formation. In the reelin pathway TBR1 work along with proteins like Reelin itself to regulate neuronal positioning promoting the correct layering of the cortex.

Associated diseases and disorders

TBR1 has strong associations with autism spectrum disorders and intellectual disabilities. Mutations in TBR1 disrupt its role in gene regulation during brain development leading to the aforementioned neurological conditions. TBR1 also interacts with FOXP2 a protein involved in language and speech linking it further to communication-related aspects of these disorders.

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1 product image

  • Western blot - Anti-TBR1 antibody (ab151587), expandable thumbnail

    Western blot - Anti-TBR1 antibody (ab151587)

    7.5% SDS PAGE

    All lanes: Western blot - Anti-TBR1 antibody (ab151587) at 1/1000 dilution

    Lane 1: Neuro2A whole cell lysate at 30 µg

    Lane 2: GL261 whole cell lysate at 30 µg

    Predicted band size: 74 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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