JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB203276

Anti-TBRG1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal TBRG1 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TBRG1 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

NIAM, TBRG1, Transforming growth factor beta regulator 1, Nuclear interactor of ARF and Mdm2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBRG1 antibody (AB203276)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBRG1 antibody (AB203276)

Immunohistochemical analysis of formalin-fixed and paraffin embedded rat pancreas tissue labeling TBRG1 using ab203276 at 1/200, followed by secondary detection and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TBRG1 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q3YBR2

style
left-column

Complementary Products

Primary Antibodies

AB8895

Anti-Histone H3 (mono methyl K4) antibody - ChIP Grade

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Histone H3 (mono methyl K4) antibody - ChIP Grade (AB8895)

  • 4
  • 59
Primary Antibodies

AB4174

Anti-Histone H2A.Z antibody - ChIP Grade

Western blot - Anti-Histone H2A.Z antibody - ChIP Grade (AB4174)

  • 4
  • 31
Primary Antibodies

AB10158

Anti-Histone H4 antibody - ChIP Grade

BOND RX™ Validated

Western blot - Anti-Histone H4 antibody - ChIP Grade (AB10158)

  • 4
  • 21
Primary Antibodies

AB1790

Anti-Histone H2B antibody - ChIP Grade

BOND RX™ Validated

Western blot - Anti-Histone H2B antibody - ChIP Grade (AB1790)

  • 5
  • 28
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>Use at 1/50 - 1/200 with fluorescent detection methods.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TBRG1 also known as Transforming Growth Factor Beta Regulator 1 or TBRG4 is a protein with a molecular mass of approximately 94 kDa. The gene encoding TBRG1 is located on chromosome 11 and the protein is expressed in various tissues with noticeable expression in the liver lungs and kidneys. Mechanically TBRG1 functions as a nucleolar protein. It interacts with other proteins within the nucleolus where it regulates cellular growth and proliferation by controlling ribosomal RNA biogenesis and ribosome assembly.
Biological function summary

TBRG1 has significant roles in regulating cell cycle progression and apoptosis. It acts as a checkpoint mediator ensuring that cells do not proceed through the cell cycle with damaged DNA. TBRG1 may also be part of larger protein complexes which help maintain cellular homeostasis and prevent uncontrolled cell division. By mediating these important processes TBRG1 ensures proper cellular turnover and prevents aberrant cell growth contributing to tissue integrity.

Pathways

TBRG1 prominently participates in the p53 signaling pathway and the TGF-beta signaling pathway. In the p53 pathway TBRG1 functions alongside the tumor suppressor protein p53 to induce cell cycle arrest or apoptosis in response to DNA damage. In the TGF-beta signaling pathway TBRG1 modulates the activity of SMAD proteins which are important for transmitting signals from the cell surface to the nucleus. These interactions highlight the coordination between TBRG1 and other key proteins maintaining the balance between cell survival and death.

TBRG1's involvement in the p53 and TGF-beta pathways links it to cancer and fibrosis. Aberrant expression or mutation of TBRG1 can disrupt normal cell cycle control leading to tumorigenesis notably in liver and lung cancers. Moreover dysregulation of TBRG1 in the TGF-beta pathway can promote excess collagen deposition contributing to fibrosis. The relationship between TBRG1 p53 and SMAD proteins illustrates the protein's role in these complex diseases offering potential avenues for therapeutic intervention.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.
See full target information TBRG1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC neuroscience 19:70 PubMed30400847

2018

PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.

Applications

Unspecified application

Species

Unspecified reactive species

Julia Adelöf,My Andersson,Michelle Porritt,Anne Petersen,Madeleine Zetterberg,John Wiseman,Malin Hernebring
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com