Mouse Monoclonal TBX2 antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human T-box transcription factor TBX2 aa 550 to C-terminus.
Preservative: 0.09% Sodium azide
Constituents: PBS
| IP | WB | IHC-P | |
|---|---|---|---|
| Human | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
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Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203).
T-box transcription factor TBX2, T-box protein 2, TBX2
Mouse Monoclonal TBX2 antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human T-box transcription factor TBX2 aa 550 to C-terminus.
Preservative: 0.09% Sodium azide
Constituents: PBS
From tissue culture supernatant
We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 27th October 2017. The following lots are still unpurified and still in stock as of 27th October 2017- GR3184445-2, and GR224182-7. Lot numbers other than GR3184445-2, and GR224182-7 will be purified. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.
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Tbx2 also known as T-box 2 is a transcription factor with a molecular weight of approximately 80 kDa. This protein is a member of the T-box family which is known for regulating gene expression through DNA binding. Tbx2 plays a role in controlling developmental processes by suppressing the expression of certain target genes. It is expressed in various tissues including heart limbs and craniofacial regions during embryonic development.
This transcription factor is influential in cellular proliferation and developmental growth. It acts as a transcriptional repressor and participates in developmental processes such as osteogenesis and limb formation. Tbx2 is commonly found in complexes with other proteins that help modulate its effects on gene expression particularly during the early stages of embryogenesis.
T-box 2 interacts importantly within the Wnt signaling and Sonic Hedgehog (Shh) pathways. These pathways are vital in developmental signaling where Tbx2 works with proteins such as beta-catenin in Wnt signaling influencing gene transcription linked to cell division and differentiation. Tbx2's role in these pathways affects the expression of key genes involved in tissue patterning and development.
Tbx2 has connections to cancer and developmental disorders. Its overexpression can lead to unchecked cell proliferation implicating it in melanoma and other cancers. Additionally its role in developmental processes links Tbx2 to disorders such as Holt-Oram syndrome through interactions with Tbx5 another member of the T-box family. Understanding Tbx2's precise functions and interactions is essential for developing therapeutic strategies targeting these diseases.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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