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AB209827

Anti-Tbx6 antibody

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(1 Publication)

Rabbit Polyclonal Tbx6 antibody. Suitable for IHC - Wmt and reacts with Zebrafish samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Zebrafish tbx6l aa 1-350.
1 Images
IHC - Wholemount - Anti-Tbx6 antibody (AB209827)
  • IHC - Wmt

Supplier Data

IHC - Wholemount - Anti-Tbx6 antibody (AB209827)

Whole mount immunohistochemical analysis of zebrafish embryo (2 days post-fertilization) labeling Tbx6 with ab209827 at a 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Zebrafish

Applications

IHC - Wmt

applications

Immunogen

Recombinant Fragment Protein within Zebrafish tbx6l aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

P79742

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCWmt" : {"fullname" : "IHC - Wholemount", "shortname":"IHC - Wmt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Zebrafish": { "IHCWmt-species-checked": "testedAndGuaranteed", "IHCWmt-species-dilution-info": "1/50 - 1/500", "IHCWmt-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store undiluted
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tbx6 also known as T-box 6 is a transcription factor with a molecular mass of approximately 51 kDa. It belongs to the T-box family which is characterized by a conserved DNA-binding domain. Tbx6 is expressed in the paraxial mesoderm an area of embryonic tissue that eventually forms somites the precursors of skeletal muscle vertebrae and dermis. The expression of Tbx6 is highly regulated during developmental stages indicating its role in embryogenesis and tissue specification.
Biological function summary

Transcription factor Tbx6 plays a significant role in mesoderm specification and somite segmentation. It functions by binding to specific DNA sequences to regulate the expression of target genes essential for somite formation. Tbx6 does not form part of any known protein complex but it interacts with other transcription factors to influence mesoderm differentiation. The precise regulation of Tbx6 activity is important for proper embryonic development ensuring that the cells undertake their correct differentiation pathways.

Pathways

Tbx6 functions in pathways critical for embryonic development including the Wnt and Notch signaling pathways. The Wnt signaling pathway regulates cell fate determination while the Notch signaling controls segmentation during somitogenesis. Tbx6 interacts with proteins such as Wnt3a and RBPJ aligning its activity in these pathways to guide the formation of somites and establish anterior-posterior patterning.

Tbx6 mutations have been associated with congenital vertebral malformations and neural tube defects. These disorders arise due to the disruption of normal somitogenesis and mesoderm development often linked to faulty signaling in the Wnt and Notch pathways. Additionally protein interactions between Tbx6 and RBPJ a component of the Notch pathway highlight their collaborative role in ensuring proper vertebral column formation. Understanding Tbx6's involvement in these pathways provides insights into potential therapeutic targets for such developmental abnormalities.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable transcriptional regulator involved in developmental processes.
See full target information tbx6l

Alternative Names

tbx6, tbx6l, T-box transcription factor TBX6L, T-box protein 6L, T-box transcription factor TBX6, T-box protein 6
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

JCI insight 3: PubMed29321375

2018

Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Aarti Asnani,Baohui Zheng,Yan Liu,You Wang,Howard H Chen,Anita Vohra,An Chi,Ivan Cornella-Taracido,Huijun Wang,Douglas G Johns,David E Sosnovik,Randall T Peterson
View all publications
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Product promise

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