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AB189871

Anti-TC-2 antibody

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Rabbit Polyclonal TC-2 antibody. Suitable for WB and reacts with Human, Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human TCN2 aa 1-250.

View Alternative Names

TC2, TCN2, Transcobalamin-2, TC-2, Transcobalamin II, TC II, TCII

1 Images
Western blot - Anti-TC-2 antibody (AB189871)
  • WB

Supplier Data

Western blot - Anti-TC-2 antibody (AB189871)

All lanes:

Western blot - Anti-TC-2 antibody (ab189871) at 1/500 dilution

Lane 1:

SW620 cell extracts

Lane 2:

MCF7 cell extracts

Lane 3:

A549 cell extracts

Lane 4:

U-25MG cell extracts

Lane 5:

Mouse kidney tissue extracts

Lane 6:

Mouse lung tissue extracts

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human TCN2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P20062

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TC-2 also known as Transcription Complex 2 is a protein with a molecular mass of approximately 45 kDa. It is widely expressed in the nucleus of various cell types especially in tissues with high transcriptional activity such as the liver and brain. As part of the transcription machinery TC-2 interacts with DNA influencing the expression of specific genes critical for cellular function.
Biological function summary

This protein facilitates the assembly of transcriptional pre-initiation complexes. TC-2 serves as a scaffolding component connecting different transcription factors and RNA polymerase II essential for gene initiation. It operates as part of a larger multi-protein complex which synchronizes the gene transcription process integrating signals that impact gene expression.

Pathways

TC-2 interacts extensively with gene regulation pathways such as the RNA polymerase II transcription pathway and the nuclear receptor signaling pathway. It is closely related to the protein transcription factor TBP in these pathways coordinating the transcription initiation process. These interactions highlight TC-2's role in the orchestration of gene expression through precise pathway integrations.

Abnormalities in TC-2 expression or function have been linked to certain cancers and neurological disorders. Aberrant expression of TC-2 can affect gene regulation contributing to the development of hepatocellular carcinoma and schizophrenia. It often involves other proteins like the p53 tumor suppressor in cancer progression and neural activity modulators in brain-related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
See full target information TCN2
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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