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AB168645

Anti-TC10 antibody

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(2 Publications)

Mouse Polyclonal TC10 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Recombinant full length protein - Human, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RHOQ.

View Alternative Names

ARHQ, RASL7A, TC10, RHOQ, Rho-related GTP-binding protein RhoQ, Ras-like protein TC10, Ras-like protein family member 7A

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-TC10 antibody (AB168645)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TC10 antibody (AB168645)

Immunofluorescence analysis of HeLa cells, labeling TC10 with ab168645 at 10 µg/ml.

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human RHOQ.

P17081

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Alternative Products

Primary Antibodies

AB32079

Anti-TC10 antibody [Y304]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-TC10 antibody [Y304] (AB32079)

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  • 1

Complementary Products

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Anti-N WASP (phospho Y256) antibody

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Primary Antibodies

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Primary Antibodies

AB52938

Anti-VAV3 antibody [EP1130Y]

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Primary Antibodies

AB272245

violetFluor™ 500 Anti-MHC Class II (I-A/I-E) antibody [M5/114.15.2]

Flow Cytometry - violetFluor™ 500 Anti-MHC Class II (I-A/I-E) antibody [M5/114.15.2] (AB272245)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TC10 protein also known as RhoQ is a small GTPase belonging to the Rho family with a molecular mass of approximately 22 kDa. This protein functions as a molecular switch cycling between an active GTP-bound state and an inactive GDP-bound state. TC10 is mainly expressed in the brain but also found in adipose tissues and muscle cells. It plays important regulatory roles in organizing the actin cytoskeleton thereby influencing cell shape polarity and movement.
Biological function summary

TC10 influences various cellular processes including glucose transport vesicle trafficking and cell migration. This protein associates with other molecules to form complexes that help guide these events. By modulating the organization of the cytoskeleton TC10 indirectly affects processes such as endocytosis and exocytosis. The protein also interacts with multiple effector proteins which further diversifies its functional capacities in cellular signaling.

Pathways

The TC10 protein is involved in the insulin signaling pathway and the lipid signaling pathway. Within the insulin signaling pathway TC10 connects with important molecules such as insulin receptor substrates that help mediate glucose uptake by cells. It is also linked to related proteins like Cdc42 another Rho family member assisting in membrane trafficking and organization. These interactions highlight TC10's role in critical cellular signal transduction processes.

Research suggests that TC10 is associated with insulin resistance a condition that can lead to type 2 diabetes and with certain neurological disorders. In insulin resistance TC10's impaired signaling leads to decreased glucose uptake which can negatively affect cellular metabolism. Moreover its regulation may tightly link with proteins like PI3K linking disturbances in TC10 function with metabolic disorders. This association makes TC10 a protein of interest in understanding and treating related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.
See full target information RHOQ
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of cell science 136: PubMed37039765

2023

Activity-dependent post-translational regulation of palmitoylating and depalmitoylating enzymes in the hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Danya Abazari,Angela R Wild,Tian Qiu,Bryan C Dickinson,Shernaz X Bamji

Proceedings of the National Academy of Sciences of the United States of America 110:20795-800 PubMed24297911

2013

Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission.

Applications

Unspecified application

Species

Unspecified reactive species

Simone Mayer,Rohit Kumar,Mamta Jaiswal,Tolga Soykan,Mohammad Reza Ahmadian,Nils Brose,Heinrich Betz,Jeong-Seop Rhee,Theofilos Papadopoulos
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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