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AB96813

Anti-TCF-25 antibody

4

(1 Review)

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(1 Publication)

Rabbit Polyclonal TCF-25 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TCF25 aa 400-650.
2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TCF-25 antibody (AB96813)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TCF-25 antibody (AB96813)

Immunohistochemical analysis of paraffin-embedded FaDu xenograft, using ab96813 antibody at 1/100 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-TCF-25 antibody (AB96813)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TCF-25 antibody (AB96813)

Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using ab96813 antibody at 1/200 dilution. Bottom picture is the same as the top one but is merged with fluorescent DNA probe.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TCF25 aa 400-650. The exact immunogen used to generate this antibody is proprietary information.

Q9BQ70

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TCF-25 also known as Transcription Factor 25 plays an important role in gene expression by regulating transcription processes. Its protein mass is approximately 25 kDa. TCF-25 is expressed broadly across several tissues with particular prominence in the brain and heart. This expression pattern suggests its involvement in critical cellular processes in these organ systems.
Biological function summary

TCF-25 modulates expression of genes involved in development and differentiation. It functions as a part of a complex with other transcription factors to regulate target genes. This complex interaction enhances its ability to control biological processes maintaining cellular homeostasis and supporting the progression of various developmental stages.

Pathways

Studies show TCF-25 plays an influential role in both Wnt and Notch signaling pathways. These pathways are important for cell fate determination and tissue development. Within these pathways TCF-25 interacts with proteins such as beta-catenin in the Wnt signaling pathway and works alongside Notch receptors in the Notch signaling pathway illustrating its integration into these significant cellular signaling networks.

Research finds TCF-25 linked to cardiovascular diseases and neuronal development disorders. Abnormalities in TCF-25 expression or function contribute to pathogenesis in conditions like congenital heart defects where its partnership with proteins like GATA4 and NKX2-5 is essential. Additionally misregulation of TCF-25 can impact neural processes potentially leading to neurological disorders through its interactions with other transcription factors.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed : 30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed : 30244831). Also acts as a transcriptional repressor : represses transcription of SRF in vitro and so may play a role in heart development (PubMed : 16574069). May play a role in cell death control (By similarity).
See full target information TCF25

Alternative Names

KIAA1049, NULP1, FKSG26, TCF25, Ribosome quality control complex subunit TCF25, Nuclear localized protein 1, Transcription factor 25, TCF-25
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 16:6122-6127 PubMed28849122

2017

Downregulation of TM7SF4 inhibits cell proliferation and metastasis of A549 cells through regulating the PI3K/AKT/mTOR signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xudong Yang,Xiaoming Song,Xiaohang Wang,Xiangyan Liu,Zhongmin Peng
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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