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AB155391

Anti-TCF19/SC1 antibody

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(2 Publications)

Rabbit Polyclonal TCF19/SC1 antibody. Suitable for IHC-P, WB and reacts with Human, Chimpanzee samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TCF19 aa 250-300.

View Alternative Names

SC1, TCF19, Transcription factor 19, TCF-19, Transcription factor SC1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TCF19/SC1 antibody (AB155391)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TCF19/SC1 antibody (AB155391)

Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human brain cerebellum white matter tissue, labelling TCF19/SC1 using ab155391 at 5 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TCF19/SC1 antibody (AB155391)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TCF19/SC1 antibody (AB155391)

Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human tonsil tissue, labelling TCF19/SC1 using ab155391 at 5 μg/ml.

Western blot - Anti-TCF19/SC1 antibody (AB155391)
  • WB

Unknown

Western blot - Anti-TCF19/SC1 antibody (AB155391)

All lanes:

Western blot - Anti-TCF19/SC1 antibody (ab155391) at 2 µg/mL

Lane 1:

293 cell lysate

Lane 2:

293 cell lysate with immunizing peptide

Secondary

All lanes:

Goat anti-rabbit Ig HRP secondary antibody

Predicted band size: 37 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Chimpanzee

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human TCF19 aa 250-300. The exact immunogen used to generate this antibody is proprietary information.

Q9Y242

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-3 µg/mL", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "5-10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1-3 µg/mL", "WB-species-notes": "<p></p>" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TCF19 also known as SC1 is a transcription factor encoded by the TCF19 gene. The protein has an approximate molecular mass of 40 kDa. TCF19 is mostly expressed in the thymus and pancreas with lower levels found in other human tissues. It acts in regulating the expression of genes involved in cell proliferation and apoptosis by binding to specific DNA sequences. Its expression patterns suggest a role in immune system and endocrine functions particularly influencing cell activity in these organs.
Biological function summary

Transcription factor 19 regulates genes related to cell cycle control and immune response. While not part of a large protein complex TCF19 interacts with other transcription factors to modulate gene expression. Its activity suggests involvement in key processes like immune cell differentiation and pancreatic function. The role of TCF19 in these processes indicates its importance for maintaining the balance between cell growth and programmed cell death important for tissue homeostasis.

Pathways

Studies highlight the involvement of TCF19 in the cell cycle and apoptosis pathways. The protein works in conjunction with other transcription factors such as NF-kB within these pathways affecting processes of cell proliferation and survival. In the apoptosis pathway TCF19 may influence the expression of pro-apoptotic genes connecting with proteins that mediate cell death as a response to stress or damage. These interactions help maintain normal cellular turnover and immune responses.

Abnormal TCF19 expression links to certain conditions such as type 1 diabetes and cancer. In type 1 diabetes TCF19 dysregulation might affect pancreatic beta cells and immune tolerance possibly altering interactions with insulin-related proteins like insulin receptor substrates. In cancer TCF19 may influence tumor progression through deregulation of apoptotic pathways associating with oncogenic proteins like MYC. These insights into TCF19's role provide potential therapeutic targets for related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.
See full target information TCF19
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Basic research in cardiology : PubMed40962957

2025

Downregulation of TCF19 and ATAD2 causes endothelial cell cycle arrest at the transition from cardiac hypertrophy to heart failure.

Applications

Unspecified application

Species

Unspecified reactive species

Elias Erny,Christoph Koentges,Debanjan Mukherjee,Luisa Wirth,Christos Kamaras,Franziska Zell,Madelon Hossfeld,Olaf Groß,Achim Lother

PLoS pathogens 14:e1006999 PubMed29709039

2018

Varicella zoster virus productively infects human natural killer cells and manipulates phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Tessa Mollie Campbell,Brian Patrick McSharry,Megan Steain,Thomas Myles Ashhurst,Barry Slobedman,Allison Abendroth
View all publications
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