Anti-Tcl1 antibody [TCL1/2079] - BSA and Azide free
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Mouse Monoclonal Tcl1 antibody. Carrier free. Suitable for WB, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TCL1A aa 1 to C-terminus.
View Alternative Names
TCL1, TCL1A, T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Protein p14 TCL1, Oncogene TCL1
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tcl1 antibody [TCL1/2079] - BSA and Azide free (AB268261)
Formalin-fixed, paraffin-embedded human tonsil tissue stained with ab268137 at 2 μg/ml in immunohistochemistry.
This data was developed using the same antibody clone in a different buffer formulation containing PBS and Sodium azide (ab268137).
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tcl1 antibody [TCL1/2079] - BSA and Azide free (AB268261)
Formalin-fixed, paraffin-embedded human lymph node tissue stained with ab268137 at 2 μg/ml in immunohistochemistry.
This data was developed using the same antibody clone in a different buffer formulation containing PBS and Sodium azide (ab268137).
- WB
Unknown
Western blot - Anti-Tcl1 antibody [TCL1/2079] - BSA and Azide free (AB268261)
This data was developed using the same antibody clone in a different buffer formulation containing PBS and Sodium azide (ab268137).
All lanes:
Western blot - Anti-Tcl1 antibody [TCL1/2079] (<a href='/en-us/products/primary-antibodies/tcl1-antibody-tcl1-2079-ab268137'>ab268137</a>) at 2 µg/mL
All lanes:
Raji (Human Burkitt's lymphoma cell line) cell lysate
Predicted band size: 13 kDa
false
- Protein Array
Unknown
Protein Array - Anti-Tcl1 antibody [TCL1/2079] - BSA and Azide free (AB268261)
Protein Array containing more than 19,000 full-length human proteins using ab268137.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
This data was developed using the same antibody clone in a different buffer formulation containing PBS and Sodium azide (ab268137).
Reactivity data
Product details
ab268261 is the carrier-free version of ab268137.
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Properties and storage information
Form
Purification technique
Purification notes
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TCL1 enhances the activity of the AKT kinase an important component of cellular signaling that modulates cell growth and survival. This protein does not form any large complex but acts through AKT phosphorylation. The activation of TCL1 leads to the promotion of cell proliferation and prevention of apoptosis especially in lymphocytes. The regulation of these cellular activities by TCL1 suggests its important role in the development of the immune system.
Pathways
The AKT signaling pathway is significantly influenced by TCL1 controlling cell growth division and apoptosis. The interaction of TCL1 with AKT activates the PI3K/AKT pathway an important signal transduction pathway promoting survival and growth in response to extracellular signals. TCL1 indirectly affects the mTOR signaling pathway through its modulation of AKT affecting protein synthesis and cell metabolism. Both pathways emphasize the broad role of TCL1 in maintaining normal cellular functions and growth regulation.
Product protocols
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Target data
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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