Anti-TCR gamma + TCR delta antibody [V65]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

TCR gamma and TCR delta are involved in recognizing antigens without presentation by major histocompatibility complex (MHC) molecules. The receptor complex allows these cells to respond to a diverse range of non-peptide antigens mostly derived from microbial origin including phosphoantigens and lipids. This enables gamma delta T-cells to bridge innate and adaptive immunity. They do not always require antigen processing and can recognize antigens directly contributing efficiently to immune surveillance and early response to infections and cellular stress.

Pathways

TCR gamma and TCR delta are important in the signaling networks that mediate immune responses. They are involved in pathways such as the nuclear factor of activated T-cells (NFAT) and mitogen-activated protein kinase (MAPK) pathways. These pathways promote the activation proliferation and differentiation of T-cells upon antigen recognition. The TCR complex including CD3 plays a role in these signal transduction events and ZAP-70 a protein tyrosine kinase is key for initiating these pathways upon TCR activation.