Anti-TCTA antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

T-cell leukemia translocation-associated gene (TCTA) also known as transcription factor GC-box binding protein 2 (GC-BP2) serves in different cellular processes. It has a molecular mass of approximately 29 kDa. Researchers frequently identify TCTA in various tissues but find high expression levels in lymphoid tissues particularly in T-cells. This protein interacts directly with DNA and other nuclear components to facilitate transcriptional regulation and response to cellular signals.

Biological function summary

TCTA acts as a regulatory protein involved in transcription modulation. It forms part of a transcriptional complex that affects gene expression linked to cell cycle control and immune responses. TCTA performs functions in cellular differentiation particularly in hematopoietic cells. Scientists believe it plays a role in establishing appropriate cellular states in response to external cues.

Pathways

TCTA integrates into the NF-kB signaling pathway and the JAK-STAT signaling pathway. These pathways support key processes like inflammation and immune system response. TCTA interacts with proteins such as NF-kB p65 and STAT3 influencing cellular outcomes like proliferation and apoptosis. Researchers consider TCTA's involvement important in maintaining normal function within these pathways ensuring balanced cellular activities.

Associated diseases and disorders

TCTA has connections to several malignancies including T-cell acute lymphoblastic leukemia. It exhibits alterations that may contribute to malignancy progression by misregulating gene expression. Furthermore researchers find links between TCTA and autoimmune diseases where abnormal TCTA function might lead to inappropriate immune activation. In these contexts it often associates with abnormalities in the expression or function of proteins such as c-Myc or STAT3 highlighting its importance in disease developments and potential therapeutic targeting.