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AB105381

Anti-TCTN1 antibody

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(2 Publications)

Rabbit Polyclonal TCTN1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TCTN1.

View Alternative Names

TECT1, UNQ9369/PRO34160, TCTN1, Tectonic-1

1 Images
Western blot - Anti-TCTN1 antibody (AB105381)
  • WB

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Western blot - Anti-TCTN1 antibody (AB105381)

Lane 1:

Western blot - Anti-TCTN1 antibody (ab105381) at 1 µg/mL

Lane 2:

Western blot - Anti-TCTN1 antibody (ab105381) at 2 µg/mL

All lanes:

Mouse kidney tissue lysate at 15 µg

Predicted band size: 63 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TCTN1. The exact immunogen used to generate this antibody is proprietary information.

Q2MV58

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tectonic family member 1 (TCTN1) also known as protein tectonic-1 is an important component of cellular function. Its molecular weight is approximately 63 kilodaltons. Primarily TCTN1 is expressed in ciliated cells and other tissues where primary cilia functions are maintained. The protein localizes to the ciliary transition zone playing an important role in ciliary development and function which makes it an important structural constituent regulating the ciliary membrane composition.
Biological function summary

TCTN1 associates with multiple ciliary proteins forming part of the tectonic complex. This complex stabilizes the transition zone in primary cilia acting as a barrier that controls the protein and ion passage between the cilia and cytoplasm. TCTN1’s interaction with other members of the tectonic family helps maintain ciliary structure and functionality which are critical in signal transduction pathways implicated in development and cell cycle regulation.

Pathways

TCTN1 functions integrally in the Hedgehog signaling pathway and is involved in Wnt signaling to some extent. This positions TCTN1 as a modulator in these pathways influencing cellular responses important for growth and differentiation. Its interaction with other proteins like GLI family members and SMO (Smoothened) highlights its role in Hedgehog signaling modulation particularly affecting gene transcription processes that direct embryonic patterning and tissue homeostasis.

TCTN1 has connections to Joubert Syndrome and Meckel-Gruber Syndrome both ciliopathies marked by dysfunctional cilia. Mutations or functional impairments in TCTN1 compromise cilia structure and signaling processes contributing to the pathogenesis of these conditions. The protein’s interaction with MKS1 and CEP290 is critical as disruptions here are noted in aforementioned disorders highlighting its importance in maintaining ciliary integrity for preventing disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity).
See full target information TCTN1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 16:1708-1714 PubMed30008857

2018

MiR-1256 suppresses proliferation and migration of non-small cell lung cancer via regulating TCTN1.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Liu,Xiuwei Wan,Zongyun Mu,Fei Li,Lei Wang,Jing Zhao,Xiaori Huang

Journal of translational medicine 12:288 PubMed25304031

2014

Expression and prognostic significance of TCTN1 in human glioblastoma.

Applications

IHC

Species

Human

Delong Meng,Yuanyuan Chen,Yingjie Zhao,Jingkun Wang,Dapeng Yun,Song Yang,Juxiang Chen,Hongyan Chen,Daru Lu
View all publications
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