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Rabbit Polyclonal TDH antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Inactive L-threonine 3-dehydrogenase, mitochondrial.

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Images

Western blot - Anti-TDH antibody (AB233402), expandable thumbnail
  • Western blot - Anti-TDH antibody (AB233402), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (AB233402), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (AB233402), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (AB233402), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.011% Proclin 300
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Full Length Protein corresponding to Human Inactive L-threonine 3-dehydrogenase, mitochondrial. Database link Q8IZJ6

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Pig
Tested
Expected

Tested
Tested

Species

Pig

Dilution info

0.5-2 µg/mL

Notes

-

Species

Human

Dilution info

0.5-2 µg/mL

Notes

-

Tested
Tested

Species

Human

Dilution info

5-20 µg/mL

Notes

-

Expected
Expected

Species

Pig

Dilution info

Use at an assay dependent concentration.

Notes

-

Alternative names

Recommended products

Rabbit Polyclonal TDH antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Inactive L-threonine 3-dehydrogenase, mitochondrial.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Full Length Protein corresponding to Human Inactive L-threonine 3-dehydrogenase, mitochondrial. Database link Q8IZJ6
Purification technique

Affinity purification Immunogen

Concentration
Loading...
Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TDH also known as trehalose-6-phosphate phosphatase plays an important role in the trehalose biosynthesis pathway by catalyzing the dephosphorylation of trehalose-6-phosphate to trehalose. This enzyme has a mass of approximately 33 kDa and is widely expressed in various tissues including the brain liver and kidney. Its activity is important for regulating trehalose levels an essential disaccharide for energy storage and stress response in organisms.

Biological function summary

Trehalose-6-phosphate phosphatase contributes significantly to cellular energy management and stress responses. In many organisms it forms part of a larger complex involved in carbohydrate metabolism. It directly impacts trehalose production which helps protect cells under osmotic and oxidative stress conditions. Through its enzymatic action TDH ensures adequate trehalose availability maintaining cellular homeostasis.

Pathways

TDH plays an integral role in the carbohydrate metabolism and stress response pathways. It associates with proteins such as trehalose synthase in the trehalose biosynthesis pathway influencing glucose metabolism. Additionally through interactions in the stress response pathway TDH can modulate the activity of proteins coordinating cellular survival under adverse conditions.

Associated diseases and disorders

Imbalances and mutations in the function of TDH link to metabolic disorders such as Diabetes Mellitus and certain neurodegenerative diseases. In the context of diabetes the enzyme's role in glucose homeostasis becomes disrupted affecting insulin signaling. Moreover its interaction with proteins like AMPK in neurodegenerative diseases suggests its participation in cellular energy regulation and protection against cell damage.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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5 product images

  • Western blot - Anti-TDH antibody (ab233402), expandable thumbnail

    Western blot - Anti-TDH antibody (ab233402)

    All lanes: Western blot - Anti-TDH antibody (ab233402) at 1 µg/mL

    Lane 1: Pig liver tissue lysate

    Lane 2: Pig kidney tissue lysate

    Lane 3: HepG2 (human liver hepatocellular carcinoma cell line) cell lysate

    Secondary

    All lanes: HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

    Predicted band size: 25 kDa

  • Western blot - Anti-TDH antibody (ab233402), expandable thumbnail

    Western blot - Anti-TDH antibody (ab233402)

    All lanes: Western blot - Anti-TDH antibody (ab233402) at 1 µg/mL

    All lanes: Recombinant human TDH protein.

    Predicted band size: 25 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (ab233402), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (ab233402)

    Formalin-fixed, paraffin-embedded human liver tissue stained for TDH using ab233402 at 30μg/mL in immunohistochemical analysis. DAB staining.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (ab233402), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (ab233402)

    Formalin-fixed, paraffin-embedded human cerebrum tissue stained for TDH using ab233402 at 20μg/mL in immunohistochemical analysis. DAB staining.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (ab233402), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (ab233402)

    Formalin-fixed, paraffin-embedded human glioma tissue stained for TDH using ab233402 at 20μg/mL in immunohistochemical analysis. DAB staining.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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