AB233402

Anti-TDH antibody

Name: Anti-TDH antibody (ab233402) | Abcam
Brand: Abcam Limited
SKU: AB233402

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(1 Publication)

Rabbit Polyclonal TDH antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TDH.

View Alternative Names

SDR14E1P, TDH, Short chain dehydrogenase/reductase family 14E member 1 pseudogene

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (AB233402)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (AB233402)

Formalin-fixed, paraffin-embedded human glioma tissue stained for TDH using ab233402 at 20μg/mL in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (AB233402)

Formalin-fixed, paraffin-embedded human cerebrum tissue stained for TDH using ab233402 at 20μg/mL in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (AB233402)

Formalin-fixed, paraffin-embedded human liver tissue stained for TDH using ab233402 at 30μg/mL in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-TDH antibody (AB233402)

All lanes:

Western blot - Anti-TDH antibody (ab233402) at 1 µg/mL

All lanes:

Recombinant human TDH protein.

Predicted band size: 25 kDa

false

Supplier Data

Western blot - Anti-TDH antibody (AB233402)

All lanes:

Western blot - Anti-TDH antibody (ab233402) at 1 µg/mL

Lane 1:

Pig liver tissue lysate

Lane 2:

Pig kidney tissue lysate

Lane 3:

HepG2 (human liver hepatocellular carcinoma cell line) cell lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TDH.

Q8IZJ6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TDH also known as trehalose-6-phosphate phosphatase plays an important role in the trehalose biosynthesis pathway by catalyzing the dephosphorylation of trehalose-6-phosphate to trehalose. This enzyme has a mass of approximately 33 kDa and is widely expressed in various tissues including the brain liver and kidney. Its activity is important for regulating trehalose levels an essential disaccharide for energy storage and stress response in organisms.

Biological function summary

Trehalose-6-phosphate phosphatase contributes significantly to cellular energy management and stress responses. In many organisms it forms part of a larger complex involved in carbohydrate metabolism. It directly impacts trehalose production which helps protect cells under osmotic and oxidative stress conditions. Through its enzymatic action TDH ensures adequate trehalose availability maintaining cellular homeostasis.

Pathways

TDH plays an integral role in the carbohydrate metabolism and stress response pathways. It associates with proteins such as trehalose synthase in the trehalose biosynthesis pathway influencing glucose metabolism. Additionally through interactions in the stress response pathway TDH can modulate the activity of proteins coordinating cellular survival under adverse conditions.

Imbalances and mutations in the function of TDH link to metabolic disorders such as Diabetes Mellitus and certain neurodegenerative diseases. In the context of diabetes the enzyme's role in glucose homeostasis becomes disrupted affecting insulin signaling. Moreover its interaction with proteins like AMPK in neurodegenerative diseases suggests its participation in cellular energy regulation and protection against cell damage.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information TDH

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed35008625

2021

Regulation and Function of Laminin A5 during Mouse and Human Decidualization.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen-Shan Yang,Hai-Yang Pan,Wen-Wen Shi,Si-Ting Chen,Ying Wang,Meng-Yuan Li,Hai-Yi Zhang,Chen Yang,Ai-Xia Liu,Zeng-Ming Yang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-TDH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (AB233402)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (AB233402)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDH antibody (AB233402)

Western blot - Anti-TDH antibody (AB233402)

Western blot - Anti-TDH antibody (AB233402)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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