Anti-TDRD3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TDRD3 also known as Tudor domain-containing protein 3 executes important functions within the cell. It has a mass of approximately 75 kDa. TDRD3 is known for its expression in various tissues with higher levels found in brain and liver. Its structural makeup includes a Tudor domain which helps it recognize and bind methylated arginine residues on proteins. The presence of such a domain is vital for its role in mRNA regulation and protein interaction.

Biological function summary

TDRD3 influences several processes related to mRNA dynamics and gene expression. It forms a part of the transcriptional co-activator complex that interacts with the RNA polymerase II machinery. Through this TDRD3 enhances transcription elongation playing a role in gene expression regulation. Additionally it interacts with other proteins like FMRP and PRMT1 establishing a close association with RNA-binding processes and methylation activities.

Pathways

The role of TDRD3 integrates into notable biological mechanisms like the mRNA processing and DNA damage response pathways. In the mRNA processing pathway TDRD3 collaborates with proteins such as CBC (cap-binding complex) which are essential for the maturation of mRNA. In the DNA damage response pathway TDRD3 works alongside factors like TopBP1 contributing to the activation and proper functioning of repair machinery.

Associated diseases and disorders

Several insights link TDRD3 to cancer and mental disorders like Fragile X syndrome. Its interaction with FMRP known for its connection to Fragile X syndrome indicates a potential role in neural development abnormalities. Moreover altered TDRD3 expression and function in cancer supports its relevance to tumor progression often in coordination with proteins involved in the DNA repair pathway such as TopBP1. Understanding these associations aids in targeting TDRD3 for therapeutic applications.