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AB241349

Anti-TDRD7 antibody

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(2 Publications)

Rabbit Polyclonal TDRD7 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TDRD7 aa 1000 to C-terminus.

View Alternative Names

PCTAIRE2BP, TDRD7, Tudor domain-containing protein 7, PCTAIRE2-binding protein, Tudor repeat associator with PCTAIRE-2, Trap

1 Images
Western blot - Anti-TDRD7 antibody (AB241349)
  • WB

Supplier Data

Western blot - Anti-TDRD7 antibody (AB241349)

Prepared using NETN lysis buffer.

All lanes:

Western blot - Anti-TDRD7 antibody (ab241349) at 0.4 µg/mL

Lane 1:

HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Lane 3:

Jurkat (Human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Predicted band size: 124 kDa

false

Exposure time: 30s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TDRD7 aa 1000 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8NHU6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antibody was affinity purified using an epitope specific to TDRD7 immobilized on solid support.
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TDRD7 also known as Tudor Domain Containing 7 is a protein involved in RNA processing and regulation. It has a molecular weight of approximately 130 kilodaltons. Researchers have identified its expression largely in the testes eyes and brain. TDRD7 belongs to the Tudor domain-containing protein family and plays an important role in maintaining cellular RNA dynamics by interacting with various molecules in RNA-related processes.
Biological function summary

TDRD7 contributes to the formation and function of ribonucleoprotein (RNP) complexes needed for germ cell development and lens maturation. It actively participates in RNA granule assembly important for RNA stabilization and localization in cells. Through its Tudor domains TDRD7 binds symmetrically dimethylated arginines on other proteins recognizing and organizing these RNP complexes effectively.

Pathways

TDRD7 integrates into RNA regulatory pathways influencing processes such as mRNA splicing and degradation. It interacts with proteins like PIWIL1 and PIWIL2 which are involved in the piRNA pathway important for maintaining genomic integrity in germ cells. TDRD7 helps mediate gene expression regulation through these pathways impacting cellular functions and organismal development.

Mutations or dysregulation of TDRD7 are associated with congenital cataracts and other lens-related diseases. Moreover it has connections with gonadal development disorders due to its critical function in the testes. Disruptions in TDRD7 can link with proteins such as CRYAA and CRYBB2 important in maintaining the transparency and refractive properties of the lens leading to cataract formation when altered.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes : probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
See full target information TDRD7
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Brain communications 4:fcac102 PubMed35602653

2022

Disruption of cellular iron homeostasis by missense variants causes severe neurodevelopmental delay, dystonia and seizures.

Applications

Unspecified application

Species

Unspecified reactive species

Nunziata Maio,Russell P Saneto,Richard Steet,Marcio A Sotero de Menezes,Cindy Skinner,Tracey A Rouault

Autophagy 17:3848-3864 PubMed33618632

2021

TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation.

Applications

Unspecified application

Species

Unspecified reactive species

Chaofeng Tu,Haiyu Li,Xuyang Liu,Ying Wang,Wei Li,Lanlan Meng,Weili Wang,Yong Li,Dongyan Li,Juan Du,Guangxiu Lu,Ge Lin,Yue-Qiu Tan
View all publications
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