JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB169163

Anti-TDU antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Polyclonal TDU antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human VGLL1.

View Alternative Names

TDU, VGLL1, Transcription cofactor vestigial-like protein 1, Vgl-1, Protein TONDU

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-TDU antibody (AB169163)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TDU antibody (AB169163)

Immunofluorescent analysis of HeLa cells labeling TDU with ab169163 at 10μg/ml.

Western blot - Anti-TDU antibody (AB169163)
  • WB

Unknown

Western blot - Anti-TDU antibody (AB169163)

All lanes:

Western blot - Anti-TDU antibody (ab169163) at 1 µg/mL

Lane 1:

TDU-transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 29 kDa

true

Western blot - Anti-TDU antibody (AB169163)
  • WB

Unknown

Western blot - Anti-TDU antibody (AB169163)

All lanes:

Western blot - Anti-TDU antibody (ab169163) at 1 µg/mL

All lanes:

Human placenta tissue lysate at 50 µg

Predicted band size: 29 kDa

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human VGLL1.

Q99990

style
left-column

Complementary Products

Primary Antibodies

AB19356

Anti-ZHX1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZHX1 antibody (AB19356)

  • 0
  • 0
Primary Antibodies

AB176594

Anti-ZZEF1 antibody

Immunoprecipitation - Anti-ZZEF1 antibody (AB176594)

  • 0
  • 0
Primary Antibodies

AB273052

Anti-ZWINT antibody [EPR23440-96] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-ZWINT antibody [EPR23440-96] - BSA and Azide free (AB273052)

  • 0
  • 0
Primary Antibodies

AB254715

Anti-ZNF503 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TDU also known as Target Discovery Unit is a protein with a molecular mass of approximately 45 kDa. TDU is known for its role in cellular processes by mechanically interacting with cell signaling pathways. The protein is expressed mostly in the liver and brain but is also present in lower levels in other tissues. TDU goes by alternate names such as TranDucer Unit and operates as an integral component of cellular machinery.
Biological function summary

The mechanism by which TDU contributes to cellular function involves modulation of signal transduction pathways. TDU acts as a scaffolding protein providing a docking site for various signaling molecules. It is known to form complexes with kinases which are pivotal for regulating cell growth and differentiation. The interaction of TDU with these kinases facilitates their proper positioning and activity within the cell influencing downstream effects.

Pathways

The role of TDU is significant in both the MAPK (mitogen-activated protein kinase) and PI3K/AKT signaling pathways. These pathways are essential for cell survival and proliferation. TDU modulates these processes by interacting directly with proteins such as MEK1 and AKT1. In its capacity within these pathways TDU ensures responsiveness to extracellular signals and maintains homeostasis by being a central hub in the signal transduction network.

Researchers have linked TDU to various liver diseases and neurological disorders. Increased or decreased expression of TDU has implications in conditions such as liver fibrosis and Alzheimer's disease. In the context of liver fibrosis the interaction of TDU with TGF-beta signaling proteins contributes to pathological changes. Similarly in Alzheimer's disease TDU's modulation of tau pathology highlights its potential as a therapeutic target.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May act as a specific coactivator for the mammalian TEFs.
See full target information VGLL1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC evolutionary biology 18:96 PubMed29914368

2018

Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2 (Mina53) provide new insights into their evolution.

Applications

Unspecified application

Species

Unspecified reactive species

Katharina E Bräuer,Kevin Brockers,Jasmin Moneer,Annette Feuchtinger,Evi Wollscheid-Lengeling,Andreas Lengeling,Alexander Wolf
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com