Goat Polyclonal TEA domain family member 2/ETF antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TEAD2 aa 200-250.
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Publications
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- Molecular therapy. Nucleic acids 26:1215-12272021PHF5A promotes colorectal cancerprogression by alternative splicing of TEAD2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYue Chang,Yulu Zhao,Liya Wang,Meijuan Wu,Chenglong He,Mengxi Huang,Zengjie Lei,Jiahe Yang,Siqi Han,Bibo Wang,Yanyan Chen,Chao Liu,Hongju Yu,Lijun Xue,Jian Geng,Yanan Chen,Tingting Dai,Lili Ren,Qian Wang,Xiaobei Liu,Xiaoyuan Chu,Cheng ChenPubMed 34853721
- Neoplasia (New York, N.Y.) 23:951-9652021mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBrent Holmes,Angelica Benavides-Serrato,Jacquelyn T Saunders,Sunil Kumar,Robert N Nishimura,Joseph GeraPubMed 34343821
- Aging 12:11530-115492020Hsa_circ_0085576 promotes clear cell renal cell carcinoma tumorigenesis and metastasis through the miR-498/YAP1 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuanghua Liu et. al.PubMed 32541093
- American journal of translational research 10:998-10112018Effect of TEAD4 on multilineage differentiation of muscle-derived stem cells.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TEAD2 aa 200-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q15562
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Dog | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1-3 µg/mL | Notes 1 hour primary incubation is recommended for this product. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Dog | Dilution info - | Notes - |
Associated Products
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2 products for Alternative Product
Target data
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Alternative names
TEF4, TEAD2, Transcriptional enhancer factor TEF-4, TEA domain family member 2, TEAD-2
Recommended products
Goat Polyclonal TEA domain family member 2/ETF antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TEAD2 aa 200-250.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TEAD2 aa 200-250. The exact immunogen used to generate this antibody is proprietary information. Database link Q15562
- Purification technique
- Affinity purification Immunogen
- Specificity
Not expected to cross-react with other TEA domain family proteins.
- Concentration
- Purification notes
Purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TEA domain family member 2 (also known as ETF or TEAD2) is a transcription factor belonging to the TEAD protein family with a molecular mass around 47 kDa. TEAD2 plays an important mechanical role in regulating gene expression by binding to enhancer regions within the DNA. You will find TEAD2 predominantly expressed in tissues such as the brain heart and skeletal muscle. This expression pattern indicates its involvement in critical cellular activities.
- Biological function summary
TEAD2 functions as a participant in the transcriptional activation of target genes by forming complexes with other cofactors such as YAP and TAZ. This complex formation facilitates the modulation of cell proliferation differentiation and apoptosis. TEAD2 activation leads to transcriptional regulation of genes promoting these cellular processes signifying its importance in maintaining tissue homeostasis and development.
- Pathways
TEAD2 participates importantly in the Hippo signaling pathway which plays a role in organ size determination and tumor suppression. The TEAD2 pathway interaction occurs via its association with YAP and TAZ proteins which transmit signals from cell surface receptors to the nucleus. Additionally involvement in Wnt signaling connects TEAD2 to a network of proteins regulating embryonic development and adult tissue homeostasis further highlighting its pathway integration.
- Associated diseases and disorders
Dysregulation of TEAD2 activity has implications in oncological processes especially concerning tumor growth and metastasis. TEAD2's association with YAP and TAZ is significant in cancer biology due to their role in constitutive pathway activation which can lead to uncontrolled cell growth. Abnormal TEAD2 signaling may also influence diseases linked to developmental malformations because of its regulatory activity in important developmental pathways.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-TEA domain family member 2/ETF antibody (ab92279)
Detected by chemiluminescence.
All lanes: Western blot - Anti-TEA domain family member 2/ETF antibody (ab92279) at 1 µg/mL
All lanes: Human colon lysate (35µg protein in RIPA buffer)
Predicted band size: 49 kDa
Western blot - Anti-TEA domain family member 2/ETF antibody (ab92279)
All lanes: Western blot - Anti-TEA domain family member 2/ETF antibody (ab92279) at 1 µg/mL
All lanes: Human ileum lysate in RIPA buffer at 35 µg
Developed using the ECL technique.
Predicted band size: 49 kDa
Observed band size: 50 kDa
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