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AB229625

Anti-TECPR1 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal TECPR1 antibody. N-terminal. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TECPR1.

View Alternative Names

KIAA1358, TECPR1, Tectonin beta-propeller repeat-containing protein 1

1 Images
Western blot - Anti-TECPR1 antibody - N-terminal (AB229625)
  • WB

Supplier Data

Western blot - Anti-TECPR1 antibody - N-terminal (AB229625)

5% SDS-PAGE

All lanes:

Western blot - Anti-TECPR1 antibody - N-terminal (ab229625) at 1/1000 dilution

Lane 1:

C2C12 (mouse myoblast cell line) whole cell extract at 60 µg

Lane 2:

Mouse brain tissue extract at 60 µg

Predicted band size: 130 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human TECPR1. The exact immunogen used to generate this antibody is proprietary information.

Q7Z6L1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TECPR1 also known as Tectonin Beta-Propeller Repeat Containing 1 is a protein playing an important role in autophagy. It has a molecular mass of approximately 96 kDa. TECPR1 is widely expressed in human tissues including the brain liver and skeletal muscles. This protein contains multiple tectonin beta-propeller repeats believed to help in forming protein-protein interactions essential for its function.
Biological function summary

The TECPR1 protein assists in the regulation and execution of the autophagy process particularly in selective autophagy or aggrephagy. By functioning as part of a protein complex it connects with components of the autophagy machinery supporting the clearance of damaged organelles and aggregation-prone proteins. Its role in maintaining cellular homeostasis is critical and indicates its involvement in the cellular defense against stress conditions.

Pathways

TECPR1 engages notably in the autophagy pathway interacting with important proteins like LC3 and ATG5. This protein is also associated with the formation of autophagosomes and their fusion with lysosomes during the degradation process. TECPR1 contributes to the maintenance of protein quality control sharing connections with other autophagic proteins necessary for these pathways.

TECPR1 mutations have connections to neurodegenerative conditions such as hereditary spastic paraplegia. These genetic changes can disrupt the autophagic process leading to the accumulation of dysfunctional proteins and organelles therefore contributing to neuronal damage. TECPR1 also relates to lysosomal storage disorders where its interaction with proteins like p62/SQSTM1 is notable showing its role in pathogenic processes involving cellular cleansing failure and aggregate formation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes : acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.
See full target information TECPR1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 10:3833-3848 PubMed32206125

2020

Interleukin 1β-mediated HOXC10 Overexpression Promotes Hepatocellular Carcinoma Metastasis by Upregulating PDPK1 and VASP.

Applications

Unspecified application

Species

Unspecified reactive species

Yunzhi Dang,Jie Chen,Weibo Feng,Chenyang Qiao,Weili Han,Yongzhan Nie,Kaichun Wu,Daiming Fan,Limin Xia
View all publications
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Product promise

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