Rabbit Polyclonal TELO2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TELO2 aa 350-500.
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Publications
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- Cell death discovery 7:1642021The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaría Del Carmen Conde-Rubio,Roman Mylonas,Christian WidmannPubMed 34226511
- Oncology reports 45:523-5342021TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZheng Guo,Xiufang Zhang,Huabin Zhu,Nanying Zhong,Xiaoning Luo,Yu Zhang,Fuping Tu,Jinghua Zhong,Xiangcai Wang,Jue He,Li HuangPubMed 33416177
- Oncotarget 7:46056-460662016Overexpression of TELO2 decreases survival in human high-grade gliomas.Applications:WB, IHCReactive species:Unspecified reactive speciesShao-Wei Feng,Ying Chen,Wen-Chiuan Tsai,Hsin-Ying Clair Chiou,Sheng-Tang Wu,Li-Chun Huang,Chin Lin,Chih-Chuan Hsieh,Yun-Ju Yang,Dueng-Yuan HuengPubMed 27329594
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human TELO2 aa 350-500. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y4R8
Reactivity data
Select an application| IHC-P | WB | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
Target data
Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.
Alternative names
KIAA0683, TELO2, Telomere length regulation protein TEL2 homolog, Protein clk-2 homolog, hCLK2
Recommended products
Rabbit Polyclonal TELO2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TELO2 aa 350-500.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human TELO2 aa 350-500. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y4R8
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
Western blot - Anti-TELO2 antibody (ab122722)
All lanes: Western blot - Anti-TELO2 antibody (ab122722) at 1/250 dilution
Lane 1: RT-4
Lane 2: U-251 MG
Lane 3: Human plasma
Lane 4: Human liver lysate
Lane 5: Human tonsil lysate
Predicted band size: 92 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TELO2 antibody (ab122722)
ab122722, at 1/50 dilution, staining TELO2 in paraffin-embedded Human urinary bladder tissue by Immunohistochemistry.
Immunocytochemistry/ Immunofluorescence - Anti-TELO2 antibody (ab122722)
ab122722, at 4 ug/ml, staining TELO2 in Human cell line U-251 MG by Immunoflourosence.
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