Rabbit Polyclonal Ten-1 antibody. N-terminal. Suitable for IHC-P, ICC/IF and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human TENM1.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TENM1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UKZ4
Reactivity data
Select an application| IHC-P | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Expected | Tested |
| Rat | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10 µg/mL | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 20 µg/mL | Notes - |
Species Human | Dilution info 20 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
Target data
Function
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). Teneurin C-terminal-associated peptide. Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity). Ten-1 intracellular domain. Induces gene transcription activation.
Alternative names
ODZ1, TNM1, TENM1, Teneurin-1, Ten-1, Protein Odd Oz/ten-m homolog 1, Tenascin-M1, Teneurin transmembrane protein 1, Ten-m1
Recommended products
Rabbit Polyclonal Ten-1 antibody. N-terminal. Suitable for IHC-P, ICC/IF and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human TENM1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TENM1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UKZ4
- Purification technique
- Affinity purification Immunogen
- Specificity
ab211297 is predicted to not cross-react with other members of the ODZ family.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Ten-1 also known as Tensin-1 is a cytoskeletal protein with a mass of around 220 kDa. This protein mainly localizes to focal adhesions structures that connect the extracellular matrix to the cytoskeleton. Ten-1 binds actin filaments and it contains several domains such as a SH2 domain enabling it to interact with phosphotyrosine residues. This protein is expressed in various tissues with higher levels in kidney liver and heart where it plays a part in maintaining cellular architecture and signal transduction.
- Biological function summary
Ten-1 functions in cell adhesion and migration by linking the cytoskeleton to integrins at focal adhesions. Sometimes Ten-1 forms complexes with other cytoskeletal proteins helping stabilize cell-extracellular matrix interactions. These complexes are essential for mechanical signal transduction and cellular responses to external stimuli. Expression and regulation of Ten-1 influence cell motility and structural integrity playing roles in tissue morphogenesis and wound healing.
- Pathways
Ten-1 significantly impacts the Rho signaling pathway influencing cell shape and motility. It does this through interactions with proteins such as Ras-related C3 botulinum toxin substrate 1 (Rac1) and Rho GTPases modulating actin filament dynamics. Another relevant pathway is the focal adhesion kinase (FAK) pathway where Ten-1 interacts with FAK affecting signaling cascades that regulate cell movement and survival. These pathways show how Ten-1 participates in processes important for cellular adaptation to different environmental conditions.
- Associated diseases and disorders
Alterations in Ten-1 expression or mutations can contribute to cancer progression and metastasis by affecting cell adhesion and migration. Studies indicate that lower levels of Ten-1 correlate with aggressive tumor phenotypes in breast and prostate cancers. Besides cancer Ten-1 interacts with proteins like vinculin which influences its role in tension transmission and force generation in cells potentially contributing to developmental disorders related to focal adhesion dysfunction. Understanding Ten-1's function in these contexts can offer insights into therapies targeting pathological cell migration and adhesion.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Immunocytochemistry/ Immunofluorescence - Anti-Ten-1 antibody - N-terminal (ab211297)
Immunofluorescent analysis of mouse brain tissue labeling Ten-1 with ab211297 at 20 μg/mL.
Immunocytochemistry/ Immunofluorescence - Anti-Ten-1 antibody - N-terminal (ab211297)
Immunohistochemical analysis of paraffin-embedded human tonsil tissue labeling Ten-1 with ab211297 at 10 μg/mL.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ten-1 antibody - N-terminal (ab211297)
Immunohistochemical analysis of paraffin-embedded human testis tissue labeling Ten-1 with ab211297 at 10 μg/mL.
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