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AB211297

Anti-Ten-1 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal Ten-1 antibody. N-terminal. Suitable for IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TENM1.

View Alternative Names

ODZ1, TNM1, TENM1, Teneurin-1, Ten-1, Protein Odd Oz/ten-m homolog 1, Tenascin-M1, Teneurin transmembrane protein 1, Ten-m1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ten-1 antibody - N-terminal (AB211297)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ten-1 antibody - N-terminal (AB211297)

Immunohistochemical analysis of paraffin-embedded human testis tissue labeling Ten-1 with ab211297 at 10 μg/mL.

Immunocytochemistry/ Immunofluorescence - Anti-Ten-1 antibody - N-terminal (AB211297)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Ten-1 antibody - N-terminal (AB211297)

Immunohistochemical analysis of paraffin-embedded human tonsil tissue labeling Ten-1 with ab211297 at 10 μg/mL.

Immunocytochemistry/ Immunofluorescence - Anti-Ten-1 antibody - N-terminal (AB211297)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Ten-1 antibody - N-terminal (AB211297)

Immunofluorescent analysis of mouse brain tissue labeling Ten-1 with ab211297 at 20 μg/mL.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human TENM1. The exact immunogen used to generate this antibody is proprietary information.

Q9UKZ4

Specificity

ab211297 is predicted to not cross-react with other members of the ODZ family.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Ten-1 also known as Tensin-1 is a cytoskeletal protein with a mass of around 220 kDa. This protein mainly localizes to focal adhesions structures that connect the extracellular matrix to the cytoskeleton. Ten-1 binds actin filaments and it contains several domains such as a SH2 domain enabling it to interact with phosphotyrosine residues. This protein is expressed in various tissues with higher levels in kidney liver and heart where it plays a part in maintaining cellular architecture and signal transduction.
Biological function summary

Ten-1 functions in cell adhesion and migration by linking the cytoskeleton to integrins at focal adhesions. Sometimes Ten-1 forms complexes with other cytoskeletal proteins helping stabilize cell-extracellular matrix interactions. These complexes are essential for mechanical signal transduction and cellular responses to external stimuli. Expression and regulation of Ten-1 influence cell motility and structural integrity playing roles in tissue morphogenesis and wound healing.

Pathways

Ten-1 significantly impacts the Rho signaling pathway influencing cell shape and motility. It does this through interactions with proteins such as Ras-related C3 botulinum toxin substrate 1 (Rac1) and Rho GTPases modulating actin filament dynamics. Another relevant pathway is the focal adhesion kinase (FAK) pathway where Ten-1 interacts with FAK affecting signaling cascades that regulate cell movement and survival. These pathways show how Ten-1 participates in processes important for cellular adaptation to different environmental conditions.

Alterations in Ten-1 expression or mutations can contribute to cancer progression and metastasis by affecting cell adhesion and migration. Studies indicate that lower levels of Ten-1 correlate with aggressive tumor phenotypes in breast and prostate cancers. Besides cancer Ten-1 interacts with proteins like vinculin which influences its role in tension transmission and force generation in cells potentially contributing to developmental disorders related to focal adhesion dysfunction. Understanding Ten-1's function in these contexts can offer insights into therapies targeting pathological cell migration and adhesion.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).. Teneurin C-terminal-associated peptide. Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Also acts as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior : attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).. Ten-1 intracellular domain. Induces gene transcription activation.
See full target information TENM1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancers 13: PubMed33670870

2021

Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling.

Applications

Unspecified application

Species

Unspecified reactive species

Ryan N Rys,Claudia M Wever,Dominique Geoffrion,Christophe Goncalves,Artin Ghassemian,Eugene Brailovski,Jeremy Ryan,Liliana Stoica,Josée Hébert,Tina Petrogiannis-Haliotis,Svetlana Dmitrienko,Saul Frenkiel,Annette Staiger,German Ott,Christian Steidl,David W Scott,Pierre Sesques,Sonia Del Rincon,Koren K Mann,Anthony Letai,Nathalie A Johnson
View all publications
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Product promise

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