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AB121887

Anti-Tenascin-N antibody

5

(1 Review)

|

(3 Publications)

Rabbit Polyclonal Tenascin-N antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TNN aa 1-150.

View Alternative Names

TNW, TNN, Tenascin-N, TN-N, Tenascin-W, TN-W

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin-N antibody (AB121887)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin-N antibody (AB121887)

Immunohistochemical analysis of human cerebral cortex tissue labeling Tenascin-N with ab121887 at a 1 : 500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin-N antibody (AB121887)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin-N antibody (AB121887)

Immunohistochemical analysis of human salivary gland tissue labeling Tenascin-N with ab121887 at a 1 : 500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin-N antibody (AB121887)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin-N antibody (AB121887)

Immunohistochemical analysis of human prostate tissue labeling Tenascin-N with ab121887 at a 1 : 500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin-N antibody (AB121887)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tenascin-N antibody (AB121887)

Immunohistochemical analysis of human breast tissue labeling Tenascin-N with ab121887 at a 1 : 500 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TNN aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q9UQP3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tenascin-N also known as TNN or Tenascin-W is a glycoprotein within the tenascin family which includes Tenascin-C Tenascin-X and Tenascin-R. It weighs approximately 150 kDa. Tenascin-N is expressed in specific tissues including the central nervous system muscle tissues and various regions of the developing skeleton. It mainly localizes in the extracellular matrix where it interacts with components like fibronectin and integrins to facilitate cellular interactions.
Biological function summary

The protein plays important roles in cell adhesion migration and proliferation. It does not typically form part of a larger complex but acts independently to modulate cellular environments. In the context of musculoskeletal development and neural tissue architecture Tenascin-N creates a scaffold that supports cell organization and tissue rigidity. It adjusts cell behavior through binding interactions impacting essential developmental signaling.

Pathways

Tenascin-N influences specific signaling cascades pertinent to skeletal and nervous system development. It interacts with the Wnt signaling pathway aligning with proteins such as β-catenin. Furthermore it modulates the PI3K/AKT pathway influencing cell survival and proliferation. These interactions reflect Tenascin-N's role in development and response to cellular stress.

Tenascin-N associates with gliomas and osteosarcomas. In glial tumors its expression levels correlate with tumor progression possibly interacting with integrin-linked proteins. Osteosarcomas display altered Tenascin-N patterns indicating a connection to abnormal osteoblast function. In these contexts Tenascin-N works alongside other tenascin family members fostering environments conducive to malignant growth and altered cellular mechanics.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Extracellular matrix protein that seems to be a ligand for ITGA8 : ITGB1, ITGAV : ITGB1 and ITGA4 : ITGB1 (By similarity) (PubMed : 17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed : 19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed : 17909022).
See full target information TNN
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of periodontal research 58:800-812 PubMed37221903

2023

ScRNA-seq links dental fibroblasts heterogeneity with mechanoresponsiveness.

Applications

Unspecified application

Species

Unspecified reactive species

Hongyuan Xu,Qinggang Dai,Xinyu Wang,Anting Jin,Yiling Yang,Xiangru Huang,Xijun Wang,Xin Gao,Siyuan Sun,Yuanqi Liu,Yanfei Zhu,Steve Gf Shen,Qian Bian,Lingyong Jiang

Journal of dental sciences 18:211-219 PubMed36643271

2023

Comparative gene expression analysis of stemness between periodontal ligament and umbilical cord tissues in humans.

Applications

Unspecified application

Species

Unspecified reactive species

Hyung-Joo Lee,Mijeong Jeon,Young-Han Kim,Seong-Oh Kim,Ko Eun Lee

Experimental and therapeutic medicine 14:2189-2193 PubMed28962140

2017

Relationship between blood lactic acid, blood procalcitonin, C-reactive protein and neonatal sepsis and corresponding prognostic significance in sick children.

Applications

Unspecified application

Species

Unspecified reactive species

Yongfeng Jia,Ying Wang,Xinhua Yu
View all publications
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