Anti-TENC1/Tensin-2 antibody

Target data

Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed : 15817639, PubMed : 23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed : 30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed : 23401856, PubMed : 30092354). Negatively regulates PI3K-AKT pathway activation (PubMed : 15817639, PubMed : 23401856, PubMed : 30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed : 28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed : 28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed : 26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed : 20069572).