AB167660

Anti-Tensin 1 antibody

Name: Anti-Tensin 1 antibody (ab167660) | Abcam
Brand: Abcam Limited
SKU: AB167660

Be the first to review this product! Submit a review

(3 Publications)

Mouse Polyclonal Tensin 1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TNS1 aa 1-400.

View Alternative Names

TNS, TNS1, Tensin-1

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human TNS1 aa 1-400. The exact immunogen used to generate this antibody is proprietary information.

Q9HBL0

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tensin 1 also known as TNS1 is a protein involved in focal adhesion dynamics and has a molecular mass of approximately 220 kDa. It belongs to the tensin family of proteins and plays essential role in linking the cytoskeleton to the extracellular matrix. Tensin 1 is mainly expressed in tissues like muscle brain and kidney suggesting its importance in maintaining cellular structure and function in these areas. The protein contains various domains including SH2 and PTEN-like regions which facilitate its multifunctional roles within the cell.

Biological function summary

Tensin 1 aids in the regulation of actin cytoskeleton organization and cell migration through its interactions with other cellular components. It participates as a component of the larger focal adhesion complex where it links integrins to the actin cytoskeleton. This connection is important for conveying mechanical signals from the extracellular environment which influence cellular movement and attachment. Tensin 1 also contributes to the modulation of cellular signaling pathways that regulate cytoskeletal remodeling impacting cell shape and motility.

Pathways

Tensin 1 plays a role in focal adhesion and integrin signaling pathways. These pathways are critical for cellular communication with the extracellular matrix and involve proteins such as FAK (Focal Adhesion Kinase) and Paxillin. Within these pathways Tensin 1 interacts with other focal adhesion proteins to influence cell survival and migration processes. Its role in these signaling pathways highlights its function in transmitting signals that control cellular dynamics and adhesion.

Researchers link Tensin 1 to conditions such as cancer and kidney disease. Altered expression or mutations of Tensin 1 correlate with increased tumor invasiveness and metastasis likely due to its influence on cell migration and adhesion. Furthermore abnormalities in Tensin 1 expression affect kidney function potentially contributing to chronic kidney disease development. In these diseases Tensin 1 interacts with proteins like integrins and other focal adhesion components which are essential in the progression and pathology of these conditions.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed : 21768292, PubMed : 28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed : 28005397). Enhances RHOA activation in the presence of DLC1 (PubMed : 26427649). Plays a role in cell polarization and migration (PubMed : 19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed : 21768292).

See full target information TNS1

style

left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Bioscience reports 41: PubMed33269380

2020

miR-152/TNS1 axis inhibits non-small cell lung cancer progression through Akt/mTOR/RhoA pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jinjin Duan,Li Wang,Liqun Shang,Shumei Yang,Hua Wu,Yongcheng Huang,Yi Miao

Acta obstetricia et gynecologica Scandinavica 98:222-231 PubMed30312486

2018

Gonadotropin-releasing hormone agonist induces downregulation of tensin 1 in women with endometriosis.

Applications

Unspecified application

Species

Unspecified reactive species

Endah Rahmawati,Wei-Chung V Yang,Yen-Ping Lei,Pawan K Maurya,Huei-Wen Chen,Chii-Ruey Tzeng

Oncotarget 9:1107-1113 PubMed29416680

2018

Elevated transgelin/TNS1 expression is a potential biomarker in human colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Huimin Zhou,Yiming Zhang,Lihao Wu,Wenrui Xie,Lan Li,Yu Yuan,Yu Chen,Ying Lin,Xinxiang He

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Tensin 1 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise