JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB178554

Anti-Tensin 3 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Tensin 3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human, African green monkey samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TNS3.

View Alternative Names

TEM6, TENS1, TPP, TNS3, Tensin-3, Tensin-like SH2 domain-containing protein 1, Tumor endothelial marker 6

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tensin 3 antibody (AB178554)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tensin 3 antibody (AB178554)

Immunohistochemical analysis of paraffin-embedded Human heart tissue labeling Tensin 3 with ab178554 at 1/50 dilution in the presence (right panel) or absence (left panel) of immunizing peptide.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, African green monkey

Applications

ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human TNS3. The exact immunogen used to generate this antibody is proprietary information.

Q68CZ2

style
left-column

Complementary Products

Primary Antibodies

AB176594

Anti-ZZEF1 antibody

Immunoprecipitation - Anti-ZZEF1 antibody (AB176594)

  • 0
  • 0
Primary Antibodies

AB202285

Anti-VPS13D antibody

Immunoprecipitation - Anti-VPS13D antibody (AB202285)

  • 0
  • 0
Primary Antibodies

AB135921

Anti-ZNF598 antibody

Western blot - Anti-ZNF598 antibody (AB135921)

  • 0
  • 0
Primary Antibodies

AB106626

Anti-ZMYM3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZMYM3 antibody (AB106626)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "African green monkey": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tensin 3 also known as TNS3 is a cytoskeletal protein with a mass of approximately 150 kDa. It functions mechanically as part of the actin cytoskeleton network. The protein is involved in linking actin filaments to integrin receptors at focal adhesions playing a significant role in the dynamics and stability of cell movement. Tensin 3 is expressed in a variety of tissues including the lung liver and intestine indicating its broad functional relevance across different cell types.
Biological function summary

This protein contributes to the regulation of cell adhesion migration and organization. Tensin 3 often associates in complexes with other tensin family members such as Tensin 1 and Tensin 2 to perform its functions. These complexes help in the remodeling of the extracellular matrix and influence cell shape. Through interactions with these proteins Tensin 3 regulates signals that are essential for the maintenance of tissue architecture and integrity.

Pathways

Tensin 3 plays an important part in integrin signaling and cell motility pathways. It interacts closely with proteins involved in these pathways such as vinculin and talin. The integrin-mediated pathways where Tensin 3 is active are critical for processes like cell migration and wound healing. Furthermore through these pathways Tensin 3 connects cellular signaling cascades to mechanical forces within cells facilitating proper cellular response to environmental changes.

Involvement of Tensin 3 is significant in certain cancers like lung cancer and fibrotic diseases. Overexpression of Tensin 3 has been linked to cancer cell invasion and metastasis. In fibrotic conditions its dysregulation affects normal tissue repair often leading to excessive scarring. In both contexts Tensin 3 interacts with signaling proteins like focal adhesion kinase (FAK) which further amplifies its effects on disease progression and tissue pathology.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed : 17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed : 17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed : 26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed : 26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed : 26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed : 35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed : 31905841).
See full target information TNS3
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Hepatology (Baltimore, Md.) 75:518-530 PubMed34633679

2021

Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathon J Graham,Sujit Mukherjee,Muhammad Yuksel,Rebeca Sanabria Mateos,Tengfei Si,Zhenlin Huang,Xiahong Huang,Hadil Abu Arqoub,Vishal Patel,Mark McPhail,Yoh Zen,Nigel Heaton,Maria Serena Longhi,Michael A Heneghan,Rodrigo Liberal,Diego Vergani,Giorgina Mieli-Vergani,Yun Ma,Bu'Hussain Hayee
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com