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AB53829

Anti-Tetanus Toxin antibody

0

(1 Review)

|

(5 Publications)

Rabbit Polyclonal Tetanus Toxin antibody. Suitable for ELISA, WB and reacts with Clostridium tetani samples. Cited in 5 publications.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Clostridium tetani

Applications

WB, ELISA

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Clostridium tetani": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Preservative: 0.098% Sodium azide Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tetanus toxin also known as tetanospasmin is a neurotoxic protein produced by the bacterium Clostridium tetani. It has a molecular mass of approximately 150 kDa. Tetanus toxin is expressed during bacterial proliferation and is later released during bacterial lysis. The toxin is composed of a heavy and light chain linked by disulfide bonds. The heavy chain aids in the binding of the toxin to nerve terminals while the light chain acts as a protease cleaving synaptobrevin on synaptic vesicle membranes.
Biological function summary

Tetanus toxin disrupts synaptic transmission at the neuromuscular junction by blocking the release of neurotransmitters. This action prevents the normal communication between nerves and muscles leading to characteristic muscle stiffness and spasms. Tetanus toxin is not part of a larger complex but operates at one of the final steps in neurotransmitter release. The light chain's enzymatic activity targets SNARE proteins which are essential for the fusion of synaptic vesicles with neuronal membranes.

Pathways

Tetanus toxin affects the synaptic vesicle cycle by inhibiting vesicle release. Its toxic effects block the exocytosis pathway required for neurotransmitter secretion. Tetanus toxin interferes with pathways involving proteins like SNAP-25 and syntaxin integral to membrane fusion and neurotransmitter release. These disruptions cascade into broader neurological pathways disturbing normal neuronal signaling and leading to the symptoms associated with tetanus.

Tetanus toxin is closely related to tetanus a serious condition characterized by muscular rigidity and spastic paralysis. The disease occurs when the toxin spreads from a wound site through the body. Tetanus toxin's activity affects proteins such as synaptobrevin which are critical in neurotransmitter release and therefore contribute to the pathological symptoms of tetanus. The toxin's role in the disease underlines its significance as a target for prevention through immunization with tetanus toxoids.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Tetanus Toxin
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:5475 PubMed37673908

2023

Ancient Clostridium DNA and variants of tetanus neurotoxins associated with human archaeological remains.

Applications

Unspecified application

Species

Unspecified reactive species

Harold P Hodgins,Pengsheng Chen,Briallen Lobb,Xin Wei,Benjamin J M Tremblay,Michael J Mansfield,Victoria C Y Lee,Pyung-Gang Lee,Jeffrey Coffin,Ana T Duggan,Alexis E Dolphin,Gabriel Renaud,Min Dong,Andrew C Doxey

Nature protocols 18:2374-2398 PubMed37328605

2023

Rapid biosynthesis of glycoprotein therapeutics and vaccines from freeze-dried bacterial cell lysates.

Applications

Unspecified application

Species

Unspecified reactive species

Jessica C Stark,Thapakorn Jaroentomeechai,Katherine F Warfel,Jasmine M Hershewe,Matthew P DeLisa,Michael C Jewett

Molecular oncology 15:1330-1344 PubMed33682324

2021

Therapeutic targeting with DABIL-4 depletes myeloid suppressor cells in 4T1 triple-negative breast cancer model.

Applications

Unspecified application

Species

Unspecified reactive species

Sadiya Parveen,Sumit Siddharth,Laurene S Cheung,Alok Kumar,Jessica Shen,John R Murphy,Dipali Sharma,William R Bishai

Applied microbiology and biotechnology 105:1683-1692 PubMed33511443

2021

The recombinant protein combined vaccine based on the fragment C of tetanus toxin and the cross-reacting material 197.

Applications

Unspecified application

Species

Unspecified reactive species

Pengdi Chai,Xiuying Pu,Jun Ge,Sulin Ren,Xiaoyu Xia,Amiao Luo,Shiwei Wang,Xiaodong Wang,Jianqiang Li

Nature communications 11:1023 PubMed32094345

2020

Multiple network properties overcome random connectivity to enable stereotypic sensory responses.

Applications

Unspecified application

Species

Unspecified reactive species

Aarush Mohit Mittal,Diksha Gupta,Amrita Singh,Andrew C Lin,Nitin Gupta
View all publications
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Product promise

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