Mouse Monoclonal TETX antibody. Suitable for ELISA and reacts with Clostridium tetani samples. Cited in 4 publications.
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 2.9% Sodium chloride, 0.0268% PBS
| ELISA | |
|---|---|
| Clostridium tetani | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Clostridium tetani | Dilution info 1/12500 | Notes - |
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Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
CTC_p60, tetX, Tetanus toxin, Tentoxylysin
Mouse Monoclonal TETX antibody. Suitable for ELISA and reacts with Clostridium tetani samples. Cited in 4 publications.
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 2.9% Sodium chloride, 0.0268% PBS
This antibody is specific for tetanus toxin and tetanus toxoid.
Protein A/G purified
C. tetani toxoid injected in mice is not neutralized efficiently enough by administration of this antibody to allow rescue.
Tetanus Toxoid often referred to as TT is an inactivated toxin used in vaccines to prevent tetanus. It originates from the bacterium Clostridium tetani which produces the neurotoxin tetanospasmin. This toxoid has a mass of approximately 150 kDa and is conventionally administered as a vaccine in humans and animals. It triggers an immune response without causing disease as it's a detoxified version of the toxin. Tetanus toxoid is expressed in a laboratory setting where it undergoes chemical treatment to eliminate toxicity while maintaining its antigenicity.
Tetanus toxoid stimulates the immune system to produce antibodies against the active tetanus toxin tetanospasmin. It doesn't form part of any specific protein complexes but functions independently to evoke humoral immunity. The binding of these antibodies to tetanospasmin neutralizes its effect thereby preventing the inhibition of neurotransmitter release. This process is important for avoiding the spasms and muscle rigidity associated with tetanus. The immune response it provokes includes the activation of B cells which differentiate into plasma cells that produce anti-tetanus antibodies.
Tetanus toxoid plays an integral part in the adaptive immune response. It functions within the humoral immune pathway by stimulating the Th2 response. This activation is associated with B-cell proliferation and differentiation into antibody-secreting cells which provide long-term immunity. The vaccine-related immune response connects to key immunological proteins like CD4+ T-helper cells which play a central role in modulating the immune system's response to vaccines.
The tetanus toxoid vaccine is directly related to preventing tetanus an acute often fatal infection marked by severe muscle contractions. By inducing immunity tetanus toxoid plays a preventive role against tetanospasmin-mediated dysfunction in the nervous system. Additionally the concept of herd immunity associated with tetanus prevention helps in protecting community members including those unvaccinated. No other direct protein associations in disorders are typically highlighted but successful immunization inherently aids in broader public health by reducing incidences of infection.
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