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AB68494

Anti-Tetanus Toxoid antibody

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(1 Publication)

Goat Polyclonal TETX antibody. Suitable for ID, ELISA and reacts with Clostridium tetani samples. Cited in 1 publication.

View Alternative Names

Clostridium tetani toxoid, Tentoxylysin, Tetanus toxin, Tetanus toxin tetX

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Clostridium tetani

Applications

ELISA, ID

applications

Specificity

ab68494 reacts with Tetanus toxoid in bacterial and infected tissue samples.

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Reactivity data

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Properties and storage information

Form
Liquid
Purification notes
Purified from a series of precipitations.
Storage buffer
pH: 7.2 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tetanus Toxoid often referred to as TT is an inactivated toxin used in vaccines to prevent tetanus. It originates from the bacterium Clostridium tetani which produces the neurotoxin tetanospasmin. This toxoid has a mass of approximately 150 kDa and is conventionally administered as a vaccine in humans and animals. It triggers an immune response without causing disease as it's a detoxified version of the toxin. Tetanus toxoid is expressed in a laboratory setting where it undergoes chemical treatment to eliminate toxicity while maintaining its antigenicity.
Biological function summary

Tetanus toxoid stimulates the immune system to produce antibodies against the active tetanus toxin tetanospasmin. It doesn't form part of any specific protein complexes but functions independently to evoke humoral immunity. The binding of these antibodies to tetanospasmin neutralizes its effect thereby preventing the inhibition of neurotransmitter release. This process is important for avoiding the spasms and muscle rigidity associated with tetanus. The immune response it provokes includes the activation of B cells which differentiate into plasma cells that produce anti-tetanus antibodies.

Pathways

Tetanus toxoid plays an integral part in the adaptive immune response. It functions within the humoral immune pathway by stimulating the Th2 response. This activation is associated with B-cell proliferation and differentiation into antibody-secreting cells which provide long-term immunity. The vaccine-related immune response connects to key immunological proteins like CD4+ T-helper cells which play a central role in modulating the immune system's response to vaccines.

The tetanus toxoid vaccine is directly related to preventing tetanus an acute often fatal infection marked by severe muscle contractions. By inducing immunity tetanus toxoid plays a preventive role against tetanospasmin-mediated dysfunction in the nervous system. Additionally the concept of herd immunity associated with tetanus prevention helps in protecting community members including those unvaccinated. No other direct protein associations in disorders are typically highlighted but successful immunization inherently aids in broader public health by reducing incidences of infection.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Tetanus Toxoid
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular oncology 19:452-473 PubMed39263917

2024

ERK1/2 mitogen-activated protein kinase dimerization is essential for the regulation of cell motility.

Applications

Unspecified application

Species

Unspecified reactive species

Dalia de la Fuente-Vivas,Vincenzo Cappitelli,Rocío García-Gómez,Sara Valero-Díaz,Camilla Amato,Javier Rodriguéz,Santiago Duro-Sánchez,Alexander von Kriegsheim,Michael Grusch,José Lozano,Joaquín Arribas,Berta Casar,Piero Crespo
View all publications
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Product promise

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