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AB51883

Anti-Tetranectin antibody [5B7]

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(6 Publications)

Mouse Monoclonal Tetranectin antibody. Suitable for WB, ICC/IF and reacts with Human, Cow samples. Cited in 6 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human CLEC3B.

View Alternative Names

TNA, CLEC3B, Tetranectin, TN, C-type lectin domain family 3 member B, Plasminogen kringle 4-binding protein

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-Tetranectin antibody [5B7] (AB51883)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Tetranectin antibody [5B7] (AB51883)

Immunocytochemistry/Immunofluorescence analysis of human neutrophils labelling Tetranectin (red) with ab51883. Counterstained with DAPI. A - DAPI, B - Tetranectin, C - Overlay.

Western blot - Anti-Tetranectin antibody [5B7] (AB51883)
  • WB

Supplier Data

Western blot - Anti-Tetranectin antibody [5B7] (AB51883)

All lanes:

Western blot - Anti-Tetranectin antibody [5B7] (ab51883)

Lane 1:

Marker

Lane 2:

Human serum at 20 µL

Lane 3:

Bovine serum at 20 µL

Predicted band size: 23 kDa

false

Western blot - Anti-Tetranectin antibody [5B7] (AB51883)
  • WB

Unknown

Western blot - Anti-Tetranectin antibody [5B7] (AB51883)

All lanes:

Western blot - Anti-Tetranectin antibody [5B7] (ab51883) at 5 µg/mL

Lane 1:

Human liver tissue lysate - total protein (<a href='/en-us/products/unavailable/human-liver-tissue-lysate-total-protein-ab29889'>ab29889</a>) at 10 µg

Lane 2:

Human skeletal muscle tissue lysate - total protein (<a href='/en-us/products/unavailable/human-skeletal-muscle-tissue-lysate-total-protein-ab29330'>ab29330</a>) at 10 µg

Secondary

All lanes:

Goat polyclonal to Mouse IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Predicted band size: 23 kDa

Observed band size: 22 kDa,25 kDa,55 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

5B7

Isotype

IgG2a

Light chain type

kappa

Carrier free

No

Reacts with

Cow, Human

Applications

WB, ICC/IF

applications

Immunogen

Native Full Length Protein corresponding to Human CLEC3B.

P05452

Specificity

ab51883 is specific for amino acids 17-181 of human tetranectin monomer.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 2.9% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tetranectin also known as C-type lectin domain family 3 member B (CLEC3B) is a glycoprotein with a molecular mass of about 20 kDa. It primarily exists in the bloodstream where it acts in various physiological processes. This protein expresses itself in other tissues such as liver and lungs suggesting a broad functional role across different biological systems. Its intuitive structure and function mark it for various protein-protein interactions.
Biological function summary

Tetranectin binds specifically to plasminogen a proenzyme which plays a role in breaking down fibrin in blood clots. It is known to be a part of the fibrinolytic system where it aids in tissue remodeling and repair by promoting the activation of plasminogen to plasmin. These activities suggest an integral role in maintaining vascular health and tissue dynamics. Moreover its involvement in these processes highlights the multifunctional attributes of this protein within human biology.

Pathways

Tetranectin is a component within coagulation and fibrinolytic pathways. Its interaction with plasminogen highlights its importance in the conversion pathway of plasminogen to plasmin which is essential in dissolving fibrin clots. Additionally Tetranectin’s contributions in the extracellular matrix further connect it with other proteins such as fibronectin and vitronectin facilitating cellular infrastructure and wound healing.

Researchers have linked alterations in Tetranectin levels with various conditions particularly cancer and osteoporosis. In cancer it associates with tumor growth and metastasis due to its role in tissue remodeling and plasminogen activation. In osteoporosis diminished levels of Tetranectin correlate with impaired bone density and integrative functions. Its interaction with plasminogen within these diseases illustrates not only its importance in fibrinolytic pathways but also its potential as a biomarker for pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. Plays a role in retinal function (PubMed : 35331648).
See full target information CLEC3B
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed36232952

2022

Human Papillary and Reticular Fibroblasts Show Distinct Functions on Tumor Behavior in 3D-Organotypic Cultures Mimicking Melanoma and HNSCC.

Applications

Unspecified application

Species

Unspecified reactive species

Shidi Wu,Marion Rietveld,Marieke Hogervorst,Frank de Gruijl,Sjoerd van der Burg,Maarten Vermeer,Remco van Doorn,Marij Welters,Abdoelwaheb El Ghalbzouri

Cell discovery 8:58 PubMed35725971

2022

Single-cell RNA sequencing of subcutaneous adipose tissues identifies therapeutic targets for cancer-associated lymphedema.

Applications

Unspecified application

Species

Unspecified reactive species

Xuanyu Liu,Meng Yuan,Qinqin Xiang,Zhujun Li,Fen Xu,Wen Chen,Jie Chen,Jiuzuo Huang,Nanze Yu,Zhou Zhou,Xiao Long

Journal of Cancer 10:4165-4177 PubMed31413735

2019

iTRAQ-based Comparative Serum Proteomic Analysis of Prostate Cancer Patients with or without Bone Metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Yan,Binshen Chen,Shaoju Min,Yubo Gao,Yiming Zhang,Peng Xu,Chaoming Li,Jiasheng Chen,Guangheng Luo,Chunxiao Liu

Transfusion and apheresis science : official journ 55:44-52 PubMed27470710

2016

Does smoking, age or gender affect the protein phenotype of extracellular vesicles in plasma?

Applications

Unspecified application

Species

Unspecified reactive species

R Bæk,K Varming,M M Jørgensen

International journal of molecular epidemiology an 5:53-70 PubMed24959311

2014

Practical detection of a definitive biomarker panel for Alzheimer's disease; comparisons between matched plasma and cerebrospinal fluid.

Applications

ELISA

Species

Human

Joanna L Richens,Kelly-Ann Vere,Roger A Light,Daniele Soria,Jonathan Garibaldi,A David Smith,Donald Warden,Gordon Wilcock,Nin Bajaj,Kevin Morgan,Paul O'Shea

Proteomics 9:3414-24 PubMed19609957

2009

Use of narrow-range peptide IEF to improve detection of lung adenocarcinoma markers in plasma and pleural effusion.

Applications

WB

Species

Human

Maria Pernemalm,Luigi De Petris,Hanna Eriksson,Eva Brandén,Hirsh Koyi,Lena Kanter,Rolf Lewensohn,Janne Lehtiö
View all publications
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Product promise

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