AB202134

Anti-Tetranectin antibody

Name: Anti-Tetranectin antibody (ab202134) | Abcam
Brand: Abcam Limited
SKU: AB202134

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(4 Publications)

Rabbit Polyclonal Tetranectin antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CLEC3B.

View Alternative Names

TNA, CLEC3B, Tetranectin, TN, C-type lectin domain family 3 member B, Plasminogen kringle 4-binding protein

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-Tetranectin antibody (AB202134)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Tetranectin antibody (AB202134)

Immunofluorescent analysis of HeLa cells labeling Tetranectin with ab202134 at dilution 1 : 50-1 : 200. DAPI was used for nuclear staining (Blue).

Supplier Data

Western blot - Anti-Tetranectin antibody (AB202134)

All lanes:

Western blot - Anti-Tetranectin antibody (ab202134) at 1/500 dilution

Lane 1:

Mouse heart tissue lysate

Lane 2:

Rat heart tissue lysate

Predicted band size: 23 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CLEC3B.

P05452

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tetranectin also known as C-type lectin domain family 3 member B (CLEC3B) is a glycoprotein with a molecular mass of about 20 kDa. It primarily exists in the bloodstream where it acts in various physiological processes. This protein expresses itself in other tissues such as liver and lungs suggesting a broad functional role across different biological systems. Its intuitive structure and function mark it for various protein-protein interactions.

Biological function summary

Tetranectin binds specifically to plasminogen a proenzyme which plays a role in breaking down fibrin in blood clots. It is known to be a part of the fibrinolytic system where it aids in tissue remodeling and repair by promoting the activation of plasminogen to plasmin. These activities suggest an integral role in maintaining vascular health and tissue dynamics. Moreover its involvement in these processes highlights the multifunctional attributes of this protein within human biology.

Pathways

Tetranectin is a component within coagulation and fibrinolytic pathways. Its interaction with plasminogen highlights its importance in the conversion pathway of plasminogen to plasmin which is essential in dissolving fibrin clots. Additionally Tetranectin’s contributions in the extracellular matrix further connect it with other proteins such as fibronectin and vitronectin facilitating cellular infrastructure and wound healing.

Researchers have linked alterations in Tetranectin levels with various conditions particularly cancer and osteoporosis. In cancer it associates with tumor growth and metastasis due to its role in tissue remodeling and plasminogen activation. In osteoporosis diminished levels of Tetranectin correlate with impaired bone density and integrative functions. Its interaction with plasminogen within these diseases illustrates not only its importance in fibrinolytic pathways but also its potential as a biomarker for pathological conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. Plays a role in retinal function (PubMed : 35331648).

See full target information CLEC3B

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Gut microbes 16:2438828 PubMed39673545

2024

Hypusination in intestinal epithelial cells protects mice from infectious colitis.

Applications

Unspecified application

Species

Unspecified reactive species

Alain P Gobert,Caroline V Hawkins,Kamery J Williams,Lydia A Snyder,Daniel P Barry,Mohammad Asim,Margaret M Allaman,Kara M McNamara,Alberto G Delgado,Yu Wang,Shilin Zhao,Kristie L Rose,M Blanca Piazuelo,Keith T Wilson

Investigative ophthalmology & visual science 64:5 PubMed37792336

2023

Single-Cell Transcriptomics Reveals Cellular Heterogeneity and Complex Cell-Cell Communication Networks in the Mouse Cornea.

Applications

Unspecified application

Species

Unspecified reactive species

Yueh-Feng Wu,Nai-Wen Chang,Li-An Chu,Hsin-Yu Liu,Yu-Xian Zhou,Yun-Lin Pai,Yu-Sheng Yu,Chen-Hsiang Kuan,Yu-Ching Wu,Sung-Jan Lin,Hsin-Yuan Tan

Brazilian journal of medical and biological resear 53:e9693 PubMed32696821

2020

CLEC3B protects H9c2 cardiomyocytes from apoptosis caused by hypoxia via the PI3K/Akt pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Fenghua Lv,Zhuo Wang,Yanli Huang,Aoyang Si,Yulei Chen

Journal of proteomics 226:103896 PubMed32652222

2020

Novel biomarkers in cats with congestive heart failure due to primary cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Mengmeng Liu,P David Eckersall,Vladimir Mrljak,Anita Horvatić,Nicolas Guillemin,Asier Galan,Liza Köster,Anne French

View all publications

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