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AB232500

Anti-Tetranectin antibody [EPR3067] - BSA and Azide free

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(1 Publication)

Rabbit Recombinant Monoclonal Tetranectin antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

TNA, CLEC3B, Tetranectin, TN, C-type lectin domain family 3 member B, Plasminogen kringle 4-binding protein

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tetranectin antibody [EPR3067] - BSA and Azide free (AB232500)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tetranectin antibody [EPR3067] - BSA and Azide free (AB232500)

Immunohistochemical analysis of paraffin-embedded human kidney tissue tissue labeling Tetranectin with ab108999 at 1/500 dilution.

This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab108999).

Heat mediated antigen retrieval was performed before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR3067

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Product details

ab232500 is the carrier-free version of ab108999.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tetranectin also known as C-type lectin domain family 3 member B (CLEC3B) is a glycoprotein with a molecular mass of about 20 kDa. It primarily exists in the bloodstream where it acts in various physiological processes. This protein expresses itself in other tissues such as liver and lungs suggesting a broad functional role across different biological systems. Its intuitive structure and function mark it for various protein-protein interactions.
Biological function summary

Tetranectin binds specifically to plasminogen a proenzyme which plays a role in breaking down fibrin in blood clots. It is known to be a part of the fibrinolytic system where it aids in tissue remodeling and repair by promoting the activation of plasminogen to plasmin. These activities suggest an integral role in maintaining vascular health and tissue dynamics. Moreover its involvement in these processes highlights the multifunctional attributes of this protein within human biology.

Pathways

Tetranectin is a component within coagulation and fibrinolytic pathways. Its interaction with plasminogen highlights its importance in the conversion pathway of plasminogen to plasmin which is essential in dissolving fibrin clots. Additionally Tetranectin’s contributions in the extracellular matrix further connect it with other proteins such as fibronectin and vitronectin facilitating cellular infrastructure and wound healing.

Researchers have linked alterations in Tetranectin levels with various conditions particularly cancer and osteoporosis. In cancer it associates with tumor growth and metastasis due to its role in tissue remodeling and plasminogen activation. In osteoporosis diminished levels of Tetranectin correlate with impaired bone density and integrative functions. Its interaction with plasminogen within these diseases illustrates not only its importance in fibrinolytic pathways but also its potential as a biomarker for pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. Plays a role in retinal function (PubMed : 35331648).
See full target information CLEC3B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncoimmunology 11:2079182 PubMed35707221

2022

Glucose metabolism inhibitor PFK-015 combined with immune checkpoint inhibitor is an effective treatment regimen in cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Bo Zheng,Chau Wei Wong,Jia Liu,Xiao-Jing Luo,Wei-Yi Zhou,Yan-Xing Chen,Hui-Yan Luo,Zhao-Lei Zeng,Chao Ren,Xiao-Ming Xie,De-Shen Wang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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