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AB154942

Anti-THAP11 antibody

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(2 Publications)

Rabbit Polyclonal THAP11 antibody. Suitable for IHC-P, WB and reacts with Mouse, Human, Rat samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human THAP11 aa 1-300.

View Alternative Names

HRIHFB2206, THAP11, THAP domain-containing protein 11

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THAP11 antibody (AB154942)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THAP11 antibody (AB154942)

Immunohistochemical analysis of paraffin-embedded Hela xenograft, labeling THAP11 using ab154942 at 1/500.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THAP11 antibody (AB154942)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THAP11 antibody (AB154942)

Immunohistochemical analysis of paraffin-embedded RT2 xenograft, labeling THAP11 using ab154942 at 1/500.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THAP11 antibody (AB154942)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THAP11 antibody (AB154942)

Immunohistochemical analysis of paraffin-embedded C2C12 xenograft, labeling THAP11 using ab154942 at 1/500.

Western blot - Anti-THAP11 antibody (AB154942)
  • WB

Unknown

Western blot - Anti-THAP11 antibody (AB154942)

10% SDS PAGE

All lanes:

Western blot - Anti-THAP11 antibody (ab154942) at 1/3000 dilution

All lanes:

NT2D1 whole cell lysate at 30 µg

Predicted band size: 34 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human THAP11 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q96EK4

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval using heat mediated 10 mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0).</p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval using heat mediated 10 mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0).</p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval using heat mediated 10 mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0).</p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

THAP11 also known as THAP domain-containing protein 11 is a DNA-binding transcription factor with a mass of approximately 27 kDa. This protein is widely expressed in various tissues suggesting its role in fundamental cellular processes. It contains a THAP domain a zinc finger-like domain which allows it to bind to specific DNA sequences and regulate gene expression. The structure of THAP11 enables it to participate in transcriptional repression by interacting with other cofactors. Researchers have identified its presence in the nucleus indicating its function in the regulation of the genetic material.
Biological function summary

THAP11 plays a significant role in gene regulation and transcriptional control. It acts as part of a transcriptional repressor complex influencing cell proliferation and differentiation. THAP11 modulates the expression of genes that are important for maintaining cellular homeostasis and development. It interacts with other proteins and genetic elements to ensure proper cellular functioning. By controlling the expression of target genes THAP11 guides essential cellular processes impacting normal and pathological states.

Pathways

THAP11 is involved in multiple biological processes especially those related to stem cell maintenance and embryonic development. It is actively engaged in pathways like the Wnt signaling pathway where it regulates genes important for cell growth and division. THAP11 also interacts with proteins such as beta-catenin and TCF7L2 within these pathways modulating their activities to direct cell fate decisions. Its functional integration into these pathways highlights the importance of THAP11 in regulating developmental and cellular diversification processes.

THAP11 has associations with certain types of cancer such as colon cancer. Dysregulation of THAP11 expression or function can contribute to oncogenesis by disrupting normal patterns of cell growth and differentiation. It interacts with proteins like c-Myc in cancer pathways influencing tumor development and progression. Beyond cancer THAP11 mutations or malfunctions may also impact neurodevelopmental disorders where misregulation can affect normal neural differentiation and function. Understanding the role of THAP11 in these disease contexts is critical for developing therapeutic strategies.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Transcription factor, which has both transcriptional activation and repression activities (PubMed : 31905202). Also modulates chromatin accessibility (PubMed : 38361031). In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (PubMed : 26416877). May regulate the expression of genes that encode both cytoplasmic and mitochondrial ribosomal proteins (By similarity). Required for normal mitochondrial development and function. Regulates mitochondrial gene expression, including that of components of the electron transport chain (By similarity). Involved in the maintainance of pluripotency in early embryonic cells, possibly through its action on mitochondrial maturation which is required to meet high energy demands of these cells (By similarity). Required for early development of retina, preventing premature exit of retinal progenitor cells from the cell cycle. This effect may also be mediated by its action on mitochondria (By similarity). Through the regulation of MMACHC gene expression, controls cobalamin metabolism (PubMed : 28449119, PubMed : 31905202). Required for normal brain development and neural precursor differentiation (By similarity). Involved in cell growth (PubMed : 31905202).
See full target information THAP11

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of biochemical and molecular toxicology 38:e23705 PubMed38602237

2024

CircNRD1 elevates THAP domain containing 11 through sequestering microRNA-421 to inhibit gastric cancer growth and tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Anwen Liu,Jingcong Liang,Jianfeng Wen

Journal of gastrointestinal oncology 12:1704-1717 PubMed34532121

2021

The expression and prognostic value of REXO4 in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Weipeng Chen,Cheng Gao,Jianbo Shen,Lanqing Yao,Xiaoliang Liang,Zhong Chen
View all publications

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