Anti-THAP11 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

THAP11 also known as THAP domain-containing protein 11 is a DNA-binding transcription factor with a mass of approximately 27 kDa. This protein is widely expressed in various tissues suggesting its role in fundamental cellular processes. It contains a THAP domain a zinc finger-like domain which allows it to bind to specific DNA sequences and regulate gene expression. The structure of THAP11 enables it to participate in transcriptional repression by interacting with other cofactors. Researchers have identified its presence in the nucleus indicating its function in the regulation of the genetic material.

Biological function summary

THAP11 plays a significant role in gene regulation and transcriptional control. It acts as part of a transcriptional repressor complex influencing cell proliferation and differentiation. THAP11 modulates the expression of genes that are important for maintaining cellular homeostasis and development. It interacts with other proteins and genetic elements to ensure proper cellular functioning. By controlling the expression of target genes THAP11 guides essential cellular processes impacting normal and pathological states.

Pathways

THAP11 is involved in multiple biological processes especially those related to stem cell maintenance and embryonic development. It is actively engaged in pathways like the Wnt signaling pathway where it regulates genes important for cell growth and division. THAP11 also interacts with proteins such as beta-catenin and TCF7L2 within these pathways modulating their activities to direct cell fate decisions. Its functional integration into these pathways highlights the importance of THAP11 in regulating developmental and cellular diversification processes.

Associated diseases and disorders

THAP11 has associations with certain types of cancer such as colon cancer. Dysregulation of THAP11 expression or function can contribute to oncogenesis by disrupting normal patterns of cell growth and differentiation. It interacts with proteins like c-Myc in cancer pathways influencing tumor development and progression. Beyond cancer THAP11 mutations or malfunctions may also impact neurodevelopmental disorders where misregulation can affect normal neural differentiation and function. Understanding the role of THAP11 in these disease contexts is critical for developing therapeutic strategies.