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AB279380

Anti-THAP8 antibody [OTI5D11]

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Mouse Monoclonal THAP8 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human THAP8 aa 50 to C-terminus.

View Alternative Names

THAP domain-containing protein 8, THAP8

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THAP8 antibody [OTI5D11] (AB279380)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THAP8 antibody [OTI5D11] (AB279380)

Paraffin embedded human pancreas tissue stained for THAP8 using ab279380 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3minutes.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI5D11

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human THAP8 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8NA92

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

THAP8 also known as Thanatos-associated protein 8 is a member of the THAP (Thanatos-Associated Protein) domain family. It is a protein with a mass of approximately 26 kDa. THAP8 functions as a sequence-specific DNA-binding protein where it identifies and binds to specific DNA sequences potentially influencing transcription processes. In terms of its expression THAP8 is particularly expressed in testis tissue suggesting a probable role in reproductive biological processes.
Biological function summary

The activities of THAP8 involve regulating gene expression possibly by acting as a transcriptional regulator. The THAP domain allows THAP8 to participate in DNA binding and protein-protein interactions. It is not widely recognized as part of a specific protein complex but its function often interacts with DNA and other associated proteins at a molecular level indicating an individual role in cellular regulation rather than within a large complex.

Pathways

THAP8 engages primarily in the regulation of transcription-related pathways. Its DNA-binding properties can modulate transcription factors and RNA polymerase interaction. This involvement suggests potential pathways related to gene expression in testicular development and function. Although not widely linked to specific proteins within these pathways its regulatory actions imply a collaboration with transcription machinery components in gene regulation processes.

THAP8 links specifically to reproductive health issues such as infertility. Due to its high expression in testicular tissue THAP8 could influence genes essential for sperm development and maturation. Defects or dysregulation of THAP8 might indirectly interact with proteins like CREM (cAMP-responsive element modulator) known for its role in spermatogenesis which could elucidate certain male infertility cases. Understanding the exact role and connections of THAP8 in these conditions requires further investigation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information THAP8
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Product promise

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