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AB122386

Anti-THAP9 antibody

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(1 Publication)

Rabbit Polyclonal THAP9 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human THAP9 aa 700-800.

View Alternative Names

DNA transposase THAP9, THAP domain-containing protein 9, hTh9, THAP9

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-THAP9 antibody (AB122386)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-THAP9 antibody (AB122386)

Immunofluorescent staining of Human cell line U-251 MG shows positivity in mitochondria. Recommended concentration of ab122386 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THAP9 antibody (AB122386)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THAP9 antibody (AB122386)

ab122386 at 1/250 dilution staining THAP9 in paraffin-embedded Human testis tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human THAP9 aa 700-800. The exact immunogen used to generate this antibody is proprietary information.

Q9H5L6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

THAP9 also known as Thanatos-associated protein 9 is an enzyme with a molecular weight of approximately 84 kDa. This protein is part of the THAP family which is known for its DNA-binding ability through a conserved zinc finger. THAP9 is expressed in various tissues with higher expression noted in the heart liver and testes. Its function includes DNA transposition suggesting a role in genetic recombination and regulation activities.
Biological function summary

THAP9 participates in the regulation of DNA elements and may act as a transposase. It functions as part of a complex with other proteins contributing to the mobility of DNA within the genome. This activity suggests a role in maintaining genomic stability where the transposition may influence gene expression patterns and potentially affect cell differentiation and development.

Pathways

The role that THAP9 plays is particularly connected to DNA repair and replication pathways. Its activity in transposing DNA aligns it with the non-homologous end-joining pathway for DNA repair. Related proteins in these pathways include Ku70/80 and DNA-PK which THAP9 may interact with to facilitate its functions in genome maintenance and stability.

THAP9 has shown significance in genetic instability-related conditions such as cancer. The protein's role in DNA transposition may influence oncogene activation or tumor suppressor gene inactivation. Additionally it has connections to neuropsychiatric disorders possibly through its interaction with proteins like FUS linking its activity to chromosomal rearrangement and neuronal function alterations.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition.
See full target information THAP9
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 21:625 PubMed37715221

2023

Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Wensheng Deng,Jiaoyu Ai,Wanlin Zhang,Zhenyu Zhou,Muqi Li,Likun Yan,Lidong Zhang,Zongjing Huang,Ziyi Wu,Junhua Ai,Hai Jiang
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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